Transketolase-like 1 ectopic expression is associated with DNA hypomethylation and induces the Warburg effect in melanoma cells

BACKGROUND: The metabolism of cancer cells is often reprogrammed by dysregulation of metabolic enzymes. Transketolase-like 1 (TKTL1) is a homodimeric transketolase linking the pentose-phosphate pathway with the glycolytic pathway. It is generally silenced at a transcriptional level in somatic tissue...

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Detalles Bibliográficos
Autores principales: Jayachandran, Aparna, Lo, Pu-Han, Chueh, Anderly C., Prithviraj, Prashanth, Molania, Ramyar, Davalos-Salas, Mercedes, Anaka, Matthew, Walkiewicz, Marzena, Cebon, Jonathan, Behren, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763451/
https://www.ncbi.nlm.nih.gov/pubmed/26907172
http://dx.doi.org/10.1186/s12885-016-2185-5

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