Two cases of systemic mantle cell lymphoma involving the skin

Mantle cell lymphoma (MCL) is a form of non-Hodgkin lymphoma that rarely affects skin. Cutaneous involvement is non-specific but usually indicates widespread disease. Herein we present two cases of MCL with secondary skin involvement. One case presented as an acneiform eruption on the face and had a...

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Autores principales: Kazlouskaya, Viktoryia, Spizuoco, Amy, Junkins-Hopkins, Jacqueline M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763582/
https://www.ncbi.nlm.nih.gov/pubmed/26951614
http://dx.doi.org/10.4103/2229-5178.174317
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author Kazlouskaya, Viktoryia
Spizuoco, Amy
Junkins-Hopkins, Jacqueline M.
author_facet Kazlouskaya, Viktoryia
Spizuoco, Amy
Junkins-Hopkins, Jacqueline M.
author_sort Kazlouskaya, Viktoryia
collection PubMed
description Mantle cell lymphoma (MCL) is a form of non-Hodgkin lymphoma that rarely affects skin. Cutaneous involvement is non-specific but usually indicates widespread disease. Herein we present two cases of MCL with secondary skin involvement. One case presented as an acneiform eruption on the face and had aberrant expression of bcl-2 and bcl-6 with weak CD5 expression. The second presented with multiple tumors on the abdomen and thighs. In both cases expression of Cyclin-D1 by the tumor cells was seen. Both patients died shortly after the diagnosis was established.
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spelling pubmed-47635822016-03-07 Two cases of systemic mantle cell lymphoma involving the skin Kazlouskaya, Viktoryia Spizuoco, Amy Junkins-Hopkins, Jacqueline M. Indian Dermatol Online J Case Report Mantle cell lymphoma (MCL) is a form of non-Hodgkin lymphoma that rarely affects skin. Cutaneous involvement is non-specific but usually indicates widespread disease. Herein we present two cases of MCL with secondary skin involvement. One case presented as an acneiform eruption on the face and had aberrant expression of bcl-2 and bcl-6 with weak CD5 expression. The second presented with multiple tumors on the abdomen and thighs. In both cases expression of Cyclin-D1 by the tumor cells was seen. Both patients died shortly after the diagnosis was established. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC4763582/ /pubmed/26951614 http://dx.doi.org/10.4103/2229-5178.174317 Text en Copyright: © 2016 Indian Dermatology Online Journal http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Case Report
Kazlouskaya, Viktoryia
Spizuoco, Amy
Junkins-Hopkins, Jacqueline M.
Two cases of systemic mantle cell lymphoma involving the skin
title Two cases of systemic mantle cell lymphoma involving the skin
title_full Two cases of systemic mantle cell lymphoma involving the skin
title_fullStr Two cases of systemic mantle cell lymphoma involving the skin
title_full_unstemmed Two cases of systemic mantle cell lymphoma involving the skin
title_short Two cases of systemic mantle cell lymphoma involving the skin
title_sort two cases of systemic mantle cell lymphoma involving the skin
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763582/
https://www.ncbi.nlm.nih.gov/pubmed/26951614
http://dx.doi.org/10.4103/2229-5178.174317
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