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Combined treatment with caffeic and ferulic acid from Baccharis uncinella C. DC. (Asteraceae) protects against metabolic syndrome in mice
Fractionation of the EtOH extract from aerial parts of Baccharis uncinella C. DC. (Asteraceae) led to isolation of caffeic and ferulic acids, which were identified from spectroscopic and spectrometric evidence. These compounds exhibit antioxidant and anti-inflammatory properties and have been shown...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Associação Brasileira de Divulgação Científica
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763817/ https://www.ncbi.nlm.nih.gov/pubmed/26840707 http://dx.doi.org/10.1590/1414-431X20155003 |
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author | Bocco, B.M. Fernandes, G.W. Lorena, F.B. Cysneiros, R.M. Christoffolete, M.A. Grecco, S.S. Lancellotti, C.L. Romoff, P. Lago, J.H.G. Bianco, A.C. Ribeiro, M.O. |
author_facet | Bocco, B.M. Fernandes, G.W. Lorena, F.B. Cysneiros, R.M. Christoffolete, M.A. Grecco, S.S. Lancellotti, C.L. Romoff, P. Lago, J.H.G. Bianco, A.C. Ribeiro, M.O. |
author_sort | Bocco, B.M. |
collection | PubMed |
description | Fractionation of the EtOH extract from aerial parts of Baccharis uncinella C. DC. (Asteraceae) led to isolation of caffeic and ferulic acids, which were identified from spectroscopic and spectrometric evidence. These compounds exhibit antioxidant and anti-inflammatory properties and have been shown to be effective in the prevention/treatment of metabolic syndrome. This study investigated whether the combined treatment of caffeic and ferulic acids exhibits a more significant beneficial effect in a mouse model with metabolic syndrome. The combination treatment with caffeic and ferulic acids was tested for 60 days in C57 mice kept on a high-fat (40%) diet. The data obtained indicated that treatment with caffeic and ferulic acids prevented gain in body weight induced by the high-fat diet and improved hyperglycemia, hypercholesterolemia and hypertriglyceridemia. The expression of a number of metabolically relevant genes was affected in the liver of these animals, showing that caffeic and ferulic acid treatment results in increased cholesterol uptake and reduced hepatic triglyceride synthesis in the liver, which is a likely explanation for the prevention of hepatic steatosis. In conclusion, the combined treatment of caffeic and ferulic acids displayed major positive effects towards prevention of multiple aspects of the metabolic syndrome and liver steatosis in an obese mouse model. |
format | Online Article Text |
id | pubmed-4763817 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Associação Brasileira de Divulgação Científica |
record_format | MEDLINE/PubMed |
spelling | pubmed-47638172016-03-07 Combined treatment with caffeic and ferulic acid from Baccharis uncinella C. DC. (Asteraceae) protects against metabolic syndrome in mice Bocco, B.M. Fernandes, G.W. Lorena, F.B. Cysneiros, R.M. Christoffolete, M.A. Grecco, S.S. Lancellotti, C.L. Romoff, P. Lago, J.H.G. Bianco, A.C. Ribeiro, M.O. Braz J Med Biol Res Biomedical Sciences Fractionation of the EtOH extract from aerial parts of Baccharis uncinella C. DC. (Asteraceae) led to isolation of caffeic and ferulic acids, which were identified from spectroscopic and spectrometric evidence. These compounds exhibit antioxidant and anti-inflammatory properties and have been shown to be effective in the prevention/treatment of metabolic syndrome. This study investigated whether the combined treatment of caffeic and ferulic acids exhibits a more significant beneficial effect in a mouse model with metabolic syndrome. The combination treatment with caffeic and ferulic acids was tested for 60 days in C57 mice kept on a high-fat (40%) diet. The data obtained indicated that treatment with caffeic and ferulic acids prevented gain in body weight induced by the high-fat diet and improved hyperglycemia, hypercholesterolemia and hypertriglyceridemia. The expression of a number of metabolically relevant genes was affected in the liver of these animals, showing that caffeic and ferulic acid treatment results in increased cholesterol uptake and reduced hepatic triglyceride synthesis in the liver, which is a likely explanation for the prevention of hepatic steatosis. In conclusion, the combined treatment of caffeic and ferulic acids displayed major positive effects towards prevention of multiple aspects of the metabolic syndrome and liver steatosis in an obese mouse model. Associação Brasileira de Divulgação Científica 2016-02-02 /pmc/articles/PMC4763817/ /pubmed/26840707 http://dx.doi.org/10.1590/1414-431X20155003 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Biomedical Sciences Bocco, B.M. Fernandes, G.W. Lorena, F.B. Cysneiros, R.M. Christoffolete, M.A. Grecco, S.S. Lancellotti, C.L. Romoff, P. Lago, J.H.G. Bianco, A.C. Ribeiro, M.O. Combined treatment with caffeic and ferulic acid from Baccharis uncinella C. DC. (Asteraceae) protects against metabolic syndrome in mice |
title | Combined treatment with caffeic and ferulic acid from Baccharis
uncinella C. DC. (Asteraceae) protects against metabolic syndrome in
mice |
title_full | Combined treatment with caffeic and ferulic acid from Baccharis
uncinella C. DC. (Asteraceae) protects against metabolic syndrome in
mice |
title_fullStr | Combined treatment with caffeic and ferulic acid from Baccharis
uncinella C. DC. (Asteraceae) protects against metabolic syndrome in
mice |
title_full_unstemmed | Combined treatment with caffeic and ferulic acid from Baccharis
uncinella C. DC. (Asteraceae) protects against metabolic syndrome in
mice |
title_short | Combined treatment with caffeic and ferulic acid from Baccharis
uncinella C. DC. (Asteraceae) protects against metabolic syndrome in
mice |
title_sort | combined treatment with caffeic and ferulic acid from baccharis
uncinella c. dc. (asteraceae) protects against metabolic syndrome in
mice |
topic | Biomedical Sciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763817/ https://www.ncbi.nlm.nih.gov/pubmed/26840707 http://dx.doi.org/10.1590/1414-431X20155003 |
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