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Dentinal Tubule Disinfection with Propolis & Two Extracts of Azadirachta indica Against Candida albicans Biofilm Formed on Tooth Substrate

AIM: This study evaluates the disinfection of dentinal tubules using Propolis, Azadirachta indica (alcoholic and aqueous extracts), 2% chlorhexidine gel and calcium hydroxide against Candida albicans biofilm formed on tooth substrate. MATERIALS & METHOD: One hundred and five human teeth were inf...

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Detalles Bibliográficos
Autores principales: Joy Sinha, Dakshita, Garg, Paridhi, Verma, Anurag, Malik, Vibha, Maccune, Edgar Richard, Vasudeva, Agrima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763964/
https://www.ncbi.nlm.nih.gov/pubmed/26962368
http://dx.doi.org/10.2174/1874210601509010369
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author Joy Sinha, Dakshita
Garg, Paridhi
Verma, Anurag
Malik, Vibha
Maccune, Edgar Richard
Vasudeva, Agrima
author_facet Joy Sinha, Dakshita
Garg, Paridhi
Verma, Anurag
Malik, Vibha
Maccune, Edgar Richard
Vasudeva, Agrima
author_sort Joy Sinha, Dakshita
collection PubMed
description AIM: This study evaluates the disinfection of dentinal tubules using Propolis, Azadirachta indica (alcoholic and aqueous extracts), 2% chlorhexidine gel and calcium hydroxide against Candida albicans biofilm formed on tooth substrate. MATERIALS & METHOD: One hundred and five human teeth were infected with Candida albicans for 2 days. Samples were divided into 7 groups. Group I- Propolis, Group II- Alcoholic extract of Azadirachta indica, Group III- Aqueous extract of Azadirachta indica, Group IV- 2% Chlorhexidine, Group V- Calcium hydroxide, Group VI- Ethanol and Group VII- Saline (negative control). At the end of 1,3 and 5 days, the antimicrobial efficacy of medicaments against Candida albicans was assessed at the depths of 200 µm and 400 µm. RESULTS: The overall percentage inhibition of fungal growth (at 200 µm and 400 µm depth) was 99.2% with 2% chlorhexidine gel. There was no statistical difference between propolis, alcoholic extract of Azadirachta indica (neem) and 2% chlorhexidine. CONCLUSION: Propolis and alcoholic extract of Azadirachta indica performed equally well as that of 2% Chlorhexidine.
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spelling pubmed-47639642016-03-09 Dentinal Tubule Disinfection with Propolis & Two Extracts of Azadirachta indica Against Candida albicans Biofilm Formed on Tooth Substrate Joy Sinha, Dakshita Garg, Paridhi Verma, Anurag Malik, Vibha Maccune, Edgar Richard Vasudeva, Agrima Open Dent J Article AIM: This study evaluates the disinfection of dentinal tubules using Propolis, Azadirachta indica (alcoholic and aqueous extracts), 2% chlorhexidine gel and calcium hydroxide against Candida albicans biofilm formed on tooth substrate. MATERIALS & METHOD: One hundred and five human teeth were infected with Candida albicans for 2 days. Samples were divided into 7 groups. Group I- Propolis, Group II- Alcoholic extract of Azadirachta indica, Group III- Aqueous extract of Azadirachta indica, Group IV- 2% Chlorhexidine, Group V- Calcium hydroxide, Group VI- Ethanol and Group VII- Saline (negative control). At the end of 1,3 and 5 days, the antimicrobial efficacy of medicaments against Candida albicans was assessed at the depths of 200 µm and 400 µm. RESULTS: The overall percentage inhibition of fungal growth (at 200 µm and 400 µm depth) was 99.2% with 2% chlorhexidine gel. There was no statistical difference between propolis, alcoholic extract of Azadirachta indica (neem) and 2% chlorhexidine. CONCLUSION: Propolis and alcoholic extract of Azadirachta indica performed equally well as that of 2% Chlorhexidine. Bentham Science Publishers 2015-11-12 /pmc/articles/PMC4763964/ /pubmed/26962368 http://dx.doi.org/10.2174/1874210601509010369 Text en © Sinha et al.; Licensee Bentham Open. https://creativecommons.org/licenses/by/4.0/legalcode This is an open access articles licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided that the work is properly cited.
spellingShingle Article
Joy Sinha, Dakshita
Garg, Paridhi
Verma, Anurag
Malik, Vibha
Maccune, Edgar Richard
Vasudeva, Agrima
Dentinal Tubule Disinfection with Propolis & Two Extracts of Azadirachta indica Against Candida albicans Biofilm Formed on Tooth Substrate
title Dentinal Tubule Disinfection with Propolis & Two Extracts of Azadirachta indica Against Candida albicans Biofilm Formed on Tooth Substrate
title_full Dentinal Tubule Disinfection with Propolis & Two Extracts of Azadirachta indica Against Candida albicans Biofilm Formed on Tooth Substrate
title_fullStr Dentinal Tubule Disinfection with Propolis & Two Extracts of Azadirachta indica Against Candida albicans Biofilm Formed on Tooth Substrate
title_full_unstemmed Dentinal Tubule Disinfection with Propolis & Two Extracts of Azadirachta indica Against Candida albicans Biofilm Formed on Tooth Substrate
title_short Dentinal Tubule Disinfection with Propolis & Two Extracts of Azadirachta indica Against Candida albicans Biofilm Formed on Tooth Substrate
title_sort dentinal tubule disinfection with propolis & two extracts of azadirachta indica against candida albicans biofilm formed on tooth substrate
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763964/
https://www.ncbi.nlm.nih.gov/pubmed/26962368
http://dx.doi.org/10.2174/1874210601509010369
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