Cargando…

A Role of the Inflammasome in the Low Storage Capacity of the Abdominal Subcutaneous Adipose Tissue in Obese Adolescents

The innate immune cell sensor leucine-rich–containing family, pyrin domain containing 3 (NLRP3) inflammasome controls the activation of caspase-1, and the release of proinflammatory cytokines interleukin (IL)-1β and IL-18. The NLRP3 inflammasome is implicated in adipose tissue inflammation and the p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kursawe, Romy, Dixit, Vishwa D., Scherer, Philipp E., Santoro, Nicola, Narayan, Deepak, Gordillo, Ruth, Giannini, Cosimo, Lopez, Ximena, Pierpont, Bridget, Nouws, Jessica, Shulman, Gerald I., Caprio, Sonia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2016
Materias:	Metabolism
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764142/ https://www.ncbi.nlm.nih.gov/pubmed/26718495 http://dx.doi.org/10.2337/db15-1478

Ejemplares similares

Decreased Transcription of ChREBP-α/β Isoforms in Abdominal Subcutaneous Adipose Tissue of Obese Adolescents With Prediabetes or Early Type 2 Diabetes: Associations With Insulin Resistance and Hyperglycemia
por: Kursawe, Romy, et al.
Publicado: (2013)

Cellularity and Adipogenic Profile of the Abdominal Subcutaneous Adipose Tissue From Obese Adolescents: Association With Insulin Resistance and Hepatic Steatosis
por: Kursawe, Romy, et al.
Publicado: (2010)

Longitudinal Effects of MRI-Measured Hepatic Steatosis on Biomarkers of Glucose Homeostasis and Hepatic Apoptosis in Obese Youth
por: Kim, Grace, et al.
Publicado: (2013)

The Association Between Hepatic Fat Content and Liver Injury in Obese Children and Adolescents: Effects of ethnicity, insulin resistance, and common gene variants
por: Santoro, Nicola, et al.
Publicado: (2013)

The rs7903146 Variant in the TCF7L2 Gene Increases the Risk of Prediabetes/Type 2 Diabetes in Obese Adolescents by Impairing β-Cell Function and Hepatic Insulin Sensitivity
por: Cropano, Catrina, et al.
Publicado: (2017)

Adipocyte Fatty Acid Storage Factors Enhance Subcutaneous Fat Storage in Postmenopausal Women
por: Santosa, Sylvia, et al.
Publicado: (2013)

The Triglyceride-to-HDL Cholesterol Ratio: Association with insulin resistance in obese youths of different ethnic backgrounds
por: Giannini, Cosimo, et al.
Publicado: (2011)

Evidence for Early Defects in Insulin Sensitivity and Secretion Before the Onset of Glucose Dysregulation in Obese Youths : A Longitudinal Study
por: Giannini, Cosimo, et al.
Publicado: (2012)

Similar VLDL-TG Storage in Visceral and Subcutaneous Fat in Obese and Lean Women
por: Søndergaard, Esben, et al.
Publicado: (2011)

Metabolic Features of Nonalcoholic Fatty Liver (NAFL) in Obese Adolescents: Findings From a Multiethnic Cohort
por: Tricò, Domenico, et al.
Publicado: (2018)

AGING INDUCES NLRP3 INFLAMMASOME DEPENDENT ADIPOSE B CELL EXPANSION TO IMPAIR METABOLIC HOMEOSTASIS
por: Camell, Christina, et al.
Publicado: (2019)

Nlrp3 Inflammasome Activation in Type 2 Diabetes: Is It Clinically Relevant?
por: Dixit, Vishwa Deep
Publicado: (2013)

A Novel Role for Subcutaneous Adipose Tissue in Exercise-Induced Improvements in Glucose Homeostasis
por: Stanford, Kristin I., et al.
Publicado: (2015)

Co-occurrence of Risk Alleles in or Near Genes Modulating Insulin Secretion Predisposes Obese Youth to Prediabetes
por: Giannini, Cosimo, et al.
Publicado: (2014)

Comparison of Dorsocervical With Abdominal Subcutaneous Adipose Tissue in Patients With and Without Antiretroviral Therapy–Associated Lipodystrophy
por: Sevastianova, Ksenia, et al.
Publicado: (2011)

Relation of the degree of obesity in childhood to adipose tissue insulin resistance
por: Hagman, Emilia, et al.
Publicado: (2019)

A Branched-Chain Amino Acid-Related Metabolic Signature Characterizes Obese Adolescents with Non-Alcoholic Fatty Liver Disease
por: Goffredo, Martina, et al.
Publicado: (2017)

Relationship of Abdominal Visceral and Subcutaneous Adipose Tissue With Lipoprotein Particle Number and Size in Type 2 Diabetes
por: Sam, Susan, et al.
Publicado: (2008)

Mechanisms of disease: inflammasome activation and the development of type 2 diabetes
por: Grant, Ryan W., et al.
Publicado: (2013)

Impact of Physical Inactivity on Subcutaneous Adipose Tissue Metabolism in Healthy Young Male Offspring of Patients With Type 2 Diabetes
por: Højbjerre, Lise, et al.
Publicado: (2010)

Role of ceramide-to-dihydroceramide ratios for insulin resistance and non-alcoholic fatty liver disease in humans
por: Apostolopoulou, Maria, et al.
Publicado: (2020)

Glucose-Dependent Insulinotropic Polypeptide May Enhance Fatty Acid Re-esterification in Subcutaneous Abdominal Adipose Tissue in Lean Humans
por: Asmar, Meena, et al.
Publicado: (2010)

Storage Rates of Circulating Free Fatty Acid Into Adipose Tissue During Eating or Walking in Humans
por: Koutsari, Christina, et al.
Publicado: (2012)

Growth differentiation factor 15 (GDF15) is associated with non-alcoholic fatty liver disease (NAFLD) in youth with overweight or obesity
por: Galuppo, Brittany, et al.
Publicado: (2022)

Hepatic Fat Accumulation Is Modulated by the Interaction between the rs738409 Variant in the PNPLA3 Gene and the Dietary Omega6/Omega3 PUFA Intake
por: Santoro, Nicola, et al.
Publicado: (2012)

A Low ω-6 to ω-3 PUFA Ratio (n–6:n–3 PUFA) Diet to Treat Fatty Liver Disease in Obese Youth
por: Van Name, Michelle A, et al.
Publicado: (2020)

Storage of Circulating Free Fatty Acid in Adipose Tissue of Postabsorptive Humans: Quantitative Measures and Implications for Body Fat Distribution
por: Koutsari, Christina, et al.
Publicado: (2011)

Adipose Tissue Free Fatty Acid Storage In Vivo: Effects of Insulin Versus Niacin as a Control for Suppression of Lipolysis
por: Ali, Asem H., et al.
Publicado: (2015)

Intraperitoneal, subcutaneous and intravenous glucagon delivery and subsequent glucose response in rats: a randomized controlled crossover trial
por: Dirnena-Fusini, Ilze, et al.
Publicado: (2018)

Reduction of SPARC protects mice against NLRP3 inflammasome activation and obesity
por: Ryu, Seungjin, et al.
Publicado: (2023)

A Role for Adipose Tissue De Novo Lipogenesis in Glucose Homeostasis During Catch-up Growth: A Randle Cycle Favoring Fat Storage
por: Marcelino, Helena, et al.
Publicado: (2013)

Central Role of Fatty Liver in the Pathogenesis of Insulin Resistance in Obese Adolescents
por: D'Adamo, Ebe, et al.
Publicado: (2010)

VEGF-A–Expressing Adipose Tissue Shows Rapid Beiging and Enhanced Survival After Transplantation and Confers IL-4–Independent Metabolic Improvements
por: Park, Jiyoung, et al.
Publicado: (2017)

N-end Rule–Mediated Proteasomal Degradation of ATGL Promotes Lipid Storage
por: Xu, Jiesi, et al.
Publicado: (2023)

Intravenous Niacin Acutely Improves the Efficiency of Dietary Fat Storage in Lean and Obese Humans
por: Nelson, Robert H., et al.
Publicado: (2012)

Altered Brain Response to Drinking Glucose and Fructose in Obese Adolescents
por: Jastreboff, Ania M., et al.
Publicado: (2016)

Hepatic GALE Regulates Whole-Body Glucose Homeostasis by Modulating Tff3 Expression
por: Zhu, Yi, et al.
Publicado: (2017)

Skeletal Muscle Insulin Resistance Promotes Increased Hepatic De Novo Lipogenesis, Hyperlipidemia, and Hepatic Steatosis in the Elderly
por: Flannery, Clare, et al.
Publicado: (2012)

Association of Lifestyle Factors With Abdominal Subcutaneous and Visceral Adiposity: The Framingham Heart Study
por: Molenaar, Esther A., et al.
Publicado: (2009)

Disruption of Adipose Rab10-Dependent Insulin Signaling Causes Hepatic Insulin Resistance
por: Vazirani, Reema P., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_fabsdkiqfekbtfv4n5u7lnjcre