Cargando…
Hypothalamic POMC Deficiency Improves Glucose Tolerance Despite Insulin Resistance by Increasing Glycosuria
Hypothalamic proopiomelanocortin (POMC) is essential for the physiological regulation of energy balance; however, its role in glucose homeostasis remains less clear. We show that hypothalamic arcuate nucleus (Arc)POMC-deficient mice, which develop severe obesity and insulin resistance, unexpectedly...
Autores principales: | Chhabra, Kavaljit H., Adams, Jessica M., Fagel, Brian, Lam, Daniel D., Qi, Nathan, Rubinstein, Marcelo, Low, Malcolm J. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Diabetes Association
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764146/ https://www.ncbi.nlm.nih.gov/pubmed/26467632 http://dx.doi.org/10.2337/db15-0804 |
Ejemplares similares
-
Reduced renal sympathetic nerve activity contributes to elevated glycosuria and improved glucose tolerance in hypothalamus-specific Pomc knockout mice
por: Chhabra, Kavaljit H., et al.
Publicado: (2017) -
Hypothalamic POMC deficiency increases circulating adiponectin despite obesity
por: Yu, Hui, et al.
Publicado: (2020) -
Reprogramming the body weight set point by a reciprocal interaction of hypothalamic leptin sensitivity and Pomc gene expression reverts extreme obesity
por: Chhabra, Kavaljit H., et al.
Publicado: (2016) -
Hypothalamic POMC or MC4R deficiency impairs counterregulatory responses to hypoglycemia in mice
por: Tooke, Benjamin P., et al.
Publicado: (2018) -
Developmental single-cell transcriptomics of hypothalamic POMC neurons reveal the genetic trajectories of multiple neuropeptidergic phenotypes
por: Yu, Hui, et al.
Publicado: (2022)