Human Secreted Ly-6/uPAR Related Protein-1 (SLURP-1) Is a Selective Allosteric Antagonist of α7 Nicotinic Acetylcholine Receptor

SLURP-1 is a secreted toxin-like Ly-6/uPAR protein found in epithelium, sensory neurons and immune cells. Point mutations in the slurp-1 gene cause the autosomal inflammation skin disease Mal de Meleda. SLURP-1 is considered an autocrine/paracrine hormone that regulates growth and differentiation of...

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Detalles Bibliográficos
Autores principales: Lyukmanova, Ekaterina N., Shulepko, Mikhail A., Kudryavtsev, Denis, Bychkov, Maxim L., Kulbatskii, Dmitrii S., Kasheverov, Igor E., Astapova, Maria V., Feofanov, Alexey V., Thomsen, Morten S., Mikkelsen, Jens D., Shenkarev, Zakhar O., Tsetlin, Victor I., Dolgikh, Dmitry A., Kirpichnikov, Mikhail P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764493/
https://www.ncbi.nlm.nih.gov/pubmed/26905431
http://dx.doi.org/10.1371/journal.pone.0149733

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764493/
https://www.ncbi.nlm.nih.gov/pubmed/26905431
http://dx.doi.org/10.1371/journal.pone.0149733

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