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NG2 glia are required for vessel network formation during embryonic development

The NG2(+) glia, also known as polydendrocytes or oligodendrocyte precursor cells, represent a new entity among glial cell populations in the central nervous system. However, the complete repertoire of their roles is not yet identified. The embryonic NG2(+) glia originate from the Nkx2.1(+) progenit...

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Autores principales: Minocha, Shilpi, Valloton, Delphine, Brunet, Isabelle, Eichmann, Anne, Hornung, Jean-Pierre, Lebrand, Cecile
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764555/
https://www.ncbi.nlm.nih.gov/pubmed/26651999
http://dx.doi.org/10.7554/eLife.09102
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author Minocha, Shilpi
Valloton, Delphine
Brunet, Isabelle
Eichmann, Anne
Hornung, Jean-Pierre
Lebrand, Cecile
author_facet Minocha, Shilpi
Valloton, Delphine
Brunet, Isabelle
Eichmann, Anne
Hornung, Jean-Pierre
Lebrand, Cecile
author_sort Minocha, Shilpi
collection PubMed
description The NG2(+) glia, also known as polydendrocytes or oligodendrocyte precursor cells, represent a new entity among glial cell populations in the central nervous system. However, the complete repertoire of their roles is not yet identified. The embryonic NG2(+) glia originate from the Nkx2.1(+) progenitors of the ventral telencephalon. Our analysis unravels that, beginning from E12.5 until E16.5, the NG2(+) glia populate the entire dorsal telencephalon. Interestingly, their appearance temporally coincides with the establishment of blood vessel network in the embryonic brain. NG2(+) glia are closely apposed to developing cerebral vessels by being either positioned at the sprouting tip cells or tethered along the vessel walls. Absence of NG2(+) glia drastically affects the vascular development leading to severe reduction of ramifications and connections by E18.5. By revealing a novel and fundamental role for NG2(+) glia, our study brings new perspectives to mechanisms underlying proper vessels network formation in embryonic brains. DOI: http://dx.doi.org/10.7554/eLife.09102.001
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spelling pubmed-47645552016-02-25 NG2 glia are required for vessel network formation during embryonic development Minocha, Shilpi Valloton, Delphine Brunet, Isabelle Eichmann, Anne Hornung, Jean-Pierre Lebrand, Cecile eLife Neuroscience The NG2(+) glia, also known as polydendrocytes or oligodendrocyte precursor cells, represent a new entity among glial cell populations in the central nervous system. However, the complete repertoire of their roles is not yet identified. The embryonic NG2(+) glia originate from the Nkx2.1(+) progenitors of the ventral telencephalon. Our analysis unravels that, beginning from E12.5 until E16.5, the NG2(+) glia populate the entire dorsal telencephalon. Interestingly, their appearance temporally coincides with the establishment of blood vessel network in the embryonic brain. NG2(+) glia are closely apposed to developing cerebral vessels by being either positioned at the sprouting tip cells or tethered along the vessel walls. Absence of NG2(+) glia drastically affects the vascular development leading to severe reduction of ramifications and connections by E18.5. By revealing a novel and fundamental role for NG2(+) glia, our study brings new perspectives to mechanisms underlying proper vessels network formation in embryonic brains. DOI: http://dx.doi.org/10.7554/eLife.09102.001 eLife Sciences Publications, Ltd 2015-12-10 /pmc/articles/PMC4764555/ /pubmed/26651999 http://dx.doi.org/10.7554/eLife.09102 Text en © 2015, Minocha et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Minocha, Shilpi
Valloton, Delphine
Brunet, Isabelle
Eichmann, Anne
Hornung, Jean-Pierre
Lebrand, Cecile
NG2 glia are required for vessel network formation during embryonic development
title NG2 glia are required for vessel network formation during embryonic development
title_full NG2 glia are required for vessel network formation during embryonic development
title_fullStr NG2 glia are required for vessel network formation during embryonic development
title_full_unstemmed NG2 glia are required for vessel network formation during embryonic development
title_short NG2 glia are required for vessel network formation during embryonic development
title_sort ng2 glia are required for vessel network formation during embryonic development
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764555/
https://www.ncbi.nlm.nih.gov/pubmed/26651999
http://dx.doi.org/10.7554/eLife.09102
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