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NG2 glia are required for vessel network formation during embryonic development
The NG2(+) glia, also known as polydendrocytes or oligodendrocyte precursor cells, represent a new entity among glial cell populations in the central nervous system. However, the complete repertoire of their roles is not yet identified. The embryonic NG2(+) glia originate from the Nkx2.1(+) progenit...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764555/ https://www.ncbi.nlm.nih.gov/pubmed/26651999 http://dx.doi.org/10.7554/eLife.09102 |
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author | Minocha, Shilpi Valloton, Delphine Brunet, Isabelle Eichmann, Anne Hornung, Jean-Pierre Lebrand, Cecile |
author_facet | Minocha, Shilpi Valloton, Delphine Brunet, Isabelle Eichmann, Anne Hornung, Jean-Pierre Lebrand, Cecile |
author_sort | Minocha, Shilpi |
collection | PubMed |
description | The NG2(+) glia, also known as polydendrocytes or oligodendrocyte precursor cells, represent a new entity among glial cell populations in the central nervous system. However, the complete repertoire of their roles is not yet identified. The embryonic NG2(+) glia originate from the Nkx2.1(+) progenitors of the ventral telencephalon. Our analysis unravels that, beginning from E12.5 until E16.5, the NG2(+) glia populate the entire dorsal telencephalon. Interestingly, their appearance temporally coincides with the establishment of blood vessel network in the embryonic brain. NG2(+) glia are closely apposed to developing cerebral vessels by being either positioned at the sprouting tip cells or tethered along the vessel walls. Absence of NG2(+) glia drastically affects the vascular development leading to severe reduction of ramifications and connections by E18.5. By revealing a novel and fundamental role for NG2(+) glia, our study brings new perspectives to mechanisms underlying proper vessels network formation in embryonic brains. DOI: http://dx.doi.org/10.7554/eLife.09102.001 |
format | Online Article Text |
id | pubmed-4764555 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-47645552016-02-25 NG2 glia are required for vessel network formation during embryonic development Minocha, Shilpi Valloton, Delphine Brunet, Isabelle Eichmann, Anne Hornung, Jean-Pierre Lebrand, Cecile eLife Neuroscience The NG2(+) glia, also known as polydendrocytes or oligodendrocyte precursor cells, represent a new entity among glial cell populations in the central nervous system. However, the complete repertoire of their roles is not yet identified. The embryonic NG2(+) glia originate from the Nkx2.1(+) progenitors of the ventral telencephalon. Our analysis unravels that, beginning from E12.5 until E16.5, the NG2(+) glia populate the entire dorsal telencephalon. Interestingly, their appearance temporally coincides with the establishment of blood vessel network in the embryonic brain. NG2(+) glia are closely apposed to developing cerebral vessels by being either positioned at the sprouting tip cells or tethered along the vessel walls. Absence of NG2(+) glia drastically affects the vascular development leading to severe reduction of ramifications and connections by E18.5. By revealing a novel and fundamental role for NG2(+) glia, our study brings new perspectives to mechanisms underlying proper vessels network formation in embryonic brains. DOI: http://dx.doi.org/10.7554/eLife.09102.001 eLife Sciences Publications, Ltd 2015-12-10 /pmc/articles/PMC4764555/ /pubmed/26651999 http://dx.doi.org/10.7554/eLife.09102 Text en © 2015, Minocha et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Minocha, Shilpi Valloton, Delphine Brunet, Isabelle Eichmann, Anne Hornung, Jean-Pierre Lebrand, Cecile NG2 glia are required for vessel network formation during embryonic development |
title | NG2 glia are required for vessel network formation during embryonic development |
title_full | NG2 glia are required for vessel network formation during embryonic development |
title_fullStr | NG2 glia are required for vessel network formation during embryonic development |
title_full_unstemmed | NG2 glia are required for vessel network formation during embryonic development |
title_short | NG2 glia are required for vessel network formation during embryonic development |
title_sort | ng2 glia are required for vessel network formation during embryonic development |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764555/ https://www.ncbi.nlm.nih.gov/pubmed/26651999 http://dx.doi.org/10.7554/eLife.09102 |
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