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The Sec7 N-terminal regulatory domains facilitate membrane-proximal activation of the Arf1 GTPase

The Golgi complex is the central sorting compartment of eukaryotic cells. Arf guanine nucleotide exchange factors (Arf-GEFs) regulate virtually all traffic through the Golgi by activating Arf GTPase trafficking pathways. The Golgi Arf-GEFs contain multiple autoregulatory domains, but the precise mec...

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Detalles Bibliográficos
Autores principales:	Richardson, Brian C, Halaby, Steve L, Gustafson, Margaret A, Fromme, J Christopher
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2016
Materias:	Biophysics and Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764562/ https://www.ncbi.nlm.nih.gov/pubmed/26765562 http://dx.doi.org/10.7554/eLife.12411

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