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Genetic dissection of Down syndrome-associated congenital heart defects using a new mouse mapping panel

Down syndrome (DS), caused by trisomy of human chromosome 21 (Hsa21), is the most common cause of congenital heart defects (CHD), yet the genetic and mechanistic causes of these defects remain unknown. To identify dosage-sensitive genes that cause DS phenotypes, including CHD, we used chromosome eng...

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Detalles Bibliográficos
Autores principales:	Lana-Elola, Eva, Watson-Scales, Sheona, Slender, Amy, Gibbins, Dorota, Martineau, Alexandrine, Douglas, Charlotte, Mohun, Timothy, Fisher, Elizabeth MC, Tybulewicz, Victor LJ
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2016
Materias:	Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764572/ https://www.ncbi.nlm.nih.gov/pubmed/26765563 http://dx.doi.org/10.7554/eLife.11614

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