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Structural basis of nucleic-acid recognition and double-strand unwinding by the essential neuronal protein Pur-alpha

The neuronal DNA-/RNA-binding protein Pur-alpha is a transcription regulator and core factor for mRNA localization. Pur-alpha-deficient mice die after birth with pleiotropic neuronal defects. Here, we report the crystal structure of the DNA-/RNA-binding domain of Pur-alpha in complex with ssDNA. It...

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Detalles Bibliográficos
Autores principales:	Weber, Janine, Bao, Han, Hartlmüller, Christoph, Wang, Zhiqin, Windhager, Almut, Janowski, Robert, Madl, Tobias, Jin, Peng, Niessing, Dierk
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2016
Materias:	Biochemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764581/ https://www.ncbi.nlm.nih.gov/pubmed/26744780 http://dx.doi.org/10.7554/eLife.11297

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