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Bitter taste receptors confer diverse functions to neurons
Bitter compounds elicit an aversive response. In Drosophila, bitter-sensitive taste neurons coexpress many members of the Gr family of taste receptors. However, the molecular logic of bitter signaling is unknown. We used an in vivo expression approach to analyze the logic of bitter taste signaling....
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764594/ https://www.ncbi.nlm.nih.gov/pubmed/26880560 http://dx.doi.org/10.7554/eLife.11181 |
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author | Delventhal, Rebecca Carlson, John R |
author_facet | Delventhal, Rebecca Carlson, John R |
author_sort | Delventhal, Rebecca |
collection | PubMed |
description | Bitter compounds elicit an aversive response. In Drosophila, bitter-sensitive taste neurons coexpress many members of the Gr family of taste receptors. However, the molecular logic of bitter signaling is unknown. We used an in vivo expression approach to analyze the logic of bitter taste signaling. Ectopic or overexpression of bitter Grs increased endogenous responses or conferred novel responses. Surprisingly, expression of Grs also suppressed many endogenous bitter responses. Conversely, deletion of an endogenous Gr led to novel responses. Expression of individual Grs conferred strikingly different effects in different neurons. The results support a model in which bitter Grs interact, exhibiting competition, inhibition, or activation. The results have broad implications for the problem of how taste systems evolve to detect new environmental dangers. DOI: http://dx.doi.org/10.7554/eLife.11181.001 |
format | Online Article Text |
id | pubmed-4764594 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-47645942016-02-25 Bitter taste receptors confer diverse functions to neurons Delventhal, Rebecca Carlson, John R eLife Neuroscience Bitter compounds elicit an aversive response. In Drosophila, bitter-sensitive taste neurons coexpress many members of the Gr family of taste receptors. However, the molecular logic of bitter signaling is unknown. We used an in vivo expression approach to analyze the logic of bitter taste signaling. Ectopic or overexpression of bitter Grs increased endogenous responses or conferred novel responses. Surprisingly, expression of Grs also suppressed many endogenous bitter responses. Conversely, deletion of an endogenous Gr led to novel responses. Expression of individual Grs conferred strikingly different effects in different neurons. The results support a model in which bitter Grs interact, exhibiting competition, inhibition, or activation. The results have broad implications for the problem of how taste systems evolve to detect new environmental dangers. DOI: http://dx.doi.org/10.7554/eLife.11181.001 eLife Sciences Publications, Ltd 2016-02-15 /pmc/articles/PMC4764594/ /pubmed/26880560 http://dx.doi.org/10.7554/eLife.11181 Text en © 2016, Delventhal et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Delventhal, Rebecca Carlson, John R Bitter taste receptors confer diverse functions to neurons |
title | Bitter taste receptors confer diverse functions to neurons |
title_full | Bitter taste receptors confer diverse functions to neurons |
title_fullStr | Bitter taste receptors confer diverse functions to neurons |
title_full_unstemmed | Bitter taste receptors confer diverse functions to neurons |
title_short | Bitter taste receptors confer diverse functions to neurons |
title_sort | bitter taste receptors confer diverse functions to neurons |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764594/ https://www.ncbi.nlm.nih.gov/pubmed/26880560 http://dx.doi.org/10.7554/eLife.11181 |
work_keys_str_mv | AT delventhalrebecca bittertastereceptorsconferdiversefunctionstoneurons AT carlsonjohnr bittertastereceptorsconferdiversefunctionstoneurons |