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Bitter taste receptors confer diverse functions to neurons

Bitter compounds elicit an aversive response. In Drosophila, bitter-sensitive taste neurons coexpress many members of the Gr family of taste receptors. However, the molecular logic of bitter signaling is unknown. We used an in vivo expression approach to analyze the logic of bitter taste signaling....

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Detalles Bibliográficos
Autores principales: Delventhal, Rebecca, Carlson, John R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764594/
https://www.ncbi.nlm.nih.gov/pubmed/26880560
http://dx.doi.org/10.7554/eLife.11181
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author Delventhal, Rebecca
Carlson, John R
author_facet Delventhal, Rebecca
Carlson, John R
author_sort Delventhal, Rebecca
collection PubMed
description Bitter compounds elicit an aversive response. In Drosophila, bitter-sensitive taste neurons coexpress many members of the Gr family of taste receptors. However, the molecular logic of bitter signaling is unknown. We used an in vivo expression approach to analyze the logic of bitter taste signaling. Ectopic or overexpression of bitter Grs increased endogenous responses or conferred novel responses. Surprisingly, expression of Grs also suppressed many endogenous bitter responses. Conversely, deletion of an endogenous Gr led to novel responses. Expression of individual Grs conferred strikingly different effects in different neurons. The results support a model in which bitter Grs interact, exhibiting competition, inhibition, or activation. The results have broad implications for the problem of how taste systems evolve to detect new environmental dangers. DOI: http://dx.doi.org/10.7554/eLife.11181.001
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spelling pubmed-47645942016-02-25 Bitter taste receptors confer diverse functions to neurons Delventhal, Rebecca Carlson, John R eLife Neuroscience Bitter compounds elicit an aversive response. In Drosophila, bitter-sensitive taste neurons coexpress many members of the Gr family of taste receptors. However, the molecular logic of bitter signaling is unknown. We used an in vivo expression approach to analyze the logic of bitter taste signaling. Ectopic or overexpression of bitter Grs increased endogenous responses or conferred novel responses. Surprisingly, expression of Grs also suppressed many endogenous bitter responses. Conversely, deletion of an endogenous Gr led to novel responses. Expression of individual Grs conferred strikingly different effects in different neurons. The results support a model in which bitter Grs interact, exhibiting competition, inhibition, or activation. The results have broad implications for the problem of how taste systems evolve to detect new environmental dangers. DOI: http://dx.doi.org/10.7554/eLife.11181.001 eLife Sciences Publications, Ltd 2016-02-15 /pmc/articles/PMC4764594/ /pubmed/26880560 http://dx.doi.org/10.7554/eLife.11181 Text en © 2016, Delventhal et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Delventhal, Rebecca
Carlson, John R
Bitter taste receptors confer diverse functions to neurons
title Bitter taste receptors confer diverse functions to neurons
title_full Bitter taste receptors confer diverse functions to neurons
title_fullStr Bitter taste receptors confer diverse functions to neurons
title_full_unstemmed Bitter taste receptors confer diverse functions to neurons
title_short Bitter taste receptors confer diverse functions to neurons
title_sort bitter taste receptors confer diverse functions to neurons
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764594/
https://www.ncbi.nlm.nih.gov/pubmed/26880560
http://dx.doi.org/10.7554/eLife.11181
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