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Non-covalent interactions involving halogenated derivatives of capecitabine and thymidylate synthase: a computational approach

Capecitabine, a fluoropyrimidine prodrug, has been a frequently chosen ligand for the last one and half decades to inhibit thymidylate synthase (TYMS) for treatment of colorectal cancer. TYMS is a key enzyme for de novo synthesis of deoxythymidine monophosphate and subsequent synthesis of DNA. Recen...

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Detalles Bibliográficos
Autores principales:	Rahman, Adhip, Hoque, Mohammad Mazharol, Khan, Mohammad A. K., Sarwar, Mohammed G., Halim, Mohammad A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764604/ https://www.ncbi.nlm.nih.gov/pubmed/27026843 http://dx.doi.org/10.1186/s40064-016-1844-y

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