Data on interaction between adeno-associated virus and U87 cell via cRGD chemical modification

RGD tripeptide is a specific, high-affinity ligand for integrin, which is highly expressed in cancer cells. We previously reported that cRGD chemically modified AAV2 (AAV2(N587+1/azido+RGD)) showed significantly enhanced infectivity compared to RGD genetically inserted AAV2 (AAV2(N587+RGD)) (10.1016...

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Autores principales: Zhang, Chuanling, Yao, Tianzhuo, Zheng, Yongxiang, Li, Zhongjun, Zhang, Lihe, Zhou, Demin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Data Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764771/
https://www.ncbi.nlm.nih.gov/pubmed/26958635
http://dx.doi.org/10.1016/j.dib.2016.02.009
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author Zhang, Chuanling
Yao, Tianzhuo
Zheng, Yongxiang
Li, Zhongjun
Zhang, Lihe
Zhou, Demin
author_facet Zhang, Chuanling
Yao, Tianzhuo
Zheng, Yongxiang
Li, Zhongjun
Zhang, Lihe
Zhou, Demin
author_sort Zhang, Chuanling
collection PubMed
description RGD tripeptide is a specific, high-affinity ligand for integrin, which is highly expressed in cancer cells. We previously reported that cRGD chemically modified AAV2 (AAV2(N587+1/azido+RGD)) showed significantly enhanced infectivity compared to RGD genetically inserted AAV2 (AAV2(N587+RGD)) (10.1016/j.biomaterials.2015.11.066) [1]. Herein we provide the binding ability analysis of RGD modified AAV2 and U87 cell by flow cytometry and the theoretical working model of RGD–αvβ3 integrin interaction.
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spelling pubmed-47647712016-03-08 Data on interaction between adeno-associated virus and U87 cell via cRGD chemical modification Zhang, Chuanling Yao, Tianzhuo Zheng, Yongxiang Li, Zhongjun Zhang, Lihe Zhou, Demin Data Brief Data Article RGD tripeptide is a specific, high-affinity ligand for integrin, which is highly expressed in cancer cells. We previously reported that cRGD chemically modified AAV2 (AAV2(N587+1/azido+RGD)) showed significantly enhanced infectivity compared to RGD genetically inserted AAV2 (AAV2(N587+RGD)) (10.1016/j.biomaterials.2015.11.066) [1]. Herein we provide the binding ability analysis of RGD modified AAV2 and U87 cell by flow cytometry and the theoretical working model of RGD–αvβ3 integrin interaction. Elsevier 2016-02-10 /pmc/articles/PMC4764771/ /pubmed/26958635 http://dx.doi.org/10.1016/j.dib.2016.02.009 Text en © 2016 Published by Elsevier Inc. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Data Article
Zhang, Chuanling
Yao, Tianzhuo
Zheng, Yongxiang
Li, Zhongjun
Zhang, Lihe
Zhou, Demin
Data on interaction between adeno-associated virus and U87 cell via cRGD chemical modification
title Data on interaction between adeno-associated virus and U87 cell via cRGD chemical modification
title_full Data on interaction between adeno-associated virus and U87 cell via cRGD chemical modification
title_fullStr Data on interaction between adeno-associated virus and U87 cell via cRGD chemical modification
title_full_unstemmed Data on interaction between adeno-associated virus and U87 cell via cRGD chemical modification
title_short Data on interaction between adeno-associated virus and U87 cell via cRGD chemical modification
title_sort data on interaction between adeno-associated virus and u87 cell via crgd chemical modification
topic Data Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764771/
https://www.ncbi.nlm.nih.gov/pubmed/26958635
http://dx.doi.org/10.1016/j.dib.2016.02.009
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