Maintaining physical activity during refeeding improves body composition, intestinal hyperpermeability and behavior in anorectic mice

A role of gut-brain axis emerges in the pathophysiology of anorexia nervosa and maintaining adapted physical activity during refeeding remains discussed. We aimed to assess gastrointestinal protein metabolism and investigate the contribution of physical activity during refeeding in C57BL/6 mice with...

Descripción completa

Detalles Bibliográficos
Autores principales: Achamrah, Najate, Nobis, Séverine, Breton, Jonathan, Jésus, Pierre, Belmonte, Liliana, Maurer, Brigitte, Legrand, Romain, Bôle-Feysot, Christine, Rego, Jean Luc do, Goichon, Alexis, Rego, Jean Claude do, Déchelotte, Pierre, Fetissov, Sergueï O, Claeyssens, Sophie, Coëffier, Moïse
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764812/
https://www.ncbi.nlm.nih.gov/pubmed/26906060
http://dx.doi.org/10.1038/srep21887
_version_ 1782417442345058304
author Achamrah, Najate
Nobis, Séverine
Breton, Jonathan
Jésus, Pierre
Belmonte, Liliana
Maurer, Brigitte
Legrand, Romain
Bôle-Feysot, Christine
Rego, Jean Luc do
Goichon, Alexis
Rego, Jean Claude do
Déchelotte, Pierre
Fetissov, Sergueï O
Claeyssens, Sophie
Coëffier, Moïse
author_facet Achamrah, Najate
Nobis, Séverine
Breton, Jonathan
Jésus, Pierre
Belmonte, Liliana
Maurer, Brigitte
Legrand, Romain
Bôle-Feysot, Christine
Rego, Jean Luc do
Goichon, Alexis
Rego, Jean Claude do
Déchelotte, Pierre
Fetissov, Sergueï O
Claeyssens, Sophie
Coëffier, Moïse
author_sort Achamrah, Najate
collection PubMed
description A role of gut-brain axis emerges in the pathophysiology of anorexia nervosa and maintaining adapted physical activity during refeeding remains discussed. We aimed to assess gastrointestinal protein metabolism and investigate the contribution of physical activity during refeeding in C57BL/6 mice with activity-based anorexia (ABA). ABA mice exhibited lower body weight and food intake with increase of lean mass/fat mass ratio and fat oxidation. Colonic permeability was increased in ABA. Ad libitum food access was then restored and ABA group was divided into two subgroups, with access to running wheel (ABA-PA) or not (ABA-NPA). After refeeding, fat free mass was completely restored only in ABA-PA. Colonic permeability was enhanced in ABA-NPA. Finally, muscle kynurenine conversion into kynurenic acid was lower in ABA-NPA who also exhibited altered behavior. Maintaining physical activity during refeeding may thus limit colonic hyperpermeability and improve behavior in anorectic mice.
format Online
Article
Text
id pubmed-4764812
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-47648122016-03-02 Maintaining physical activity during refeeding improves body composition, intestinal hyperpermeability and behavior in anorectic mice Achamrah, Najate Nobis, Séverine Breton, Jonathan Jésus, Pierre Belmonte, Liliana Maurer, Brigitte Legrand, Romain Bôle-Feysot, Christine Rego, Jean Luc do Goichon, Alexis Rego, Jean Claude do Déchelotte, Pierre Fetissov, Sergueï O Claeyssens, Sophie Coëffier, Moïse Sci Rep Article A role of gut-brain axis emerges in the pathophysiology of anorexia nervosa and maintaining adapted physical activity during refeeding remains discussed. We aimed to assess gastrointestinal protein metabolism and investigate the contribution of physical activity during refeeding in C57BL/6 mice with activity-based anorexia (ABA). ABA mice exhibited lower body weight and food intake with increase of lean mass/fat mass ratio and fat oxidation. Colonic permeability was increased in ABA. Ad libitum food access was then restored and ABA group was divided into two subgroups, with access to running wheel (ABA-PA) or not (ABA-NPA). After refeeding, fat free mass was completely restored only in ABA-PA. Colonic permeability was enhanced in ABA-NPA. Finally, muscle kynurenine conversion into kynurenic acid was lower in ABA-NPA who also exhibited altered behavior. Maintaining physical activity during refeeding may thus limit colonic hyperpermeability and improve behavior in anorectic mice. Nature Publishing Group 2016-02-24 /pmc/articles/PMC4764812/ /pubmed/26906060 http://dx.doi.org/10.1038/srep21887 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Achamrah, Najate
Nobis, Séverine
Breton, Jonathan
Jésus, Pierre
Belmonte, Liliana
Maurer, Brigitte
Legrand, Romain
Bôle-Feysot, Christine
Rego, Jean Luc do
Goichon, Alexis
Rego, Jean Claude do
Déchelotte, Pierre
Fetissov, Sergueï O
Claeyssens, Sophie
Coëffier, Moïse
Maintaining physical activity during refeeding improves body composition, intestinal hyperpermeability and behavior in anorectic mice
title Maintaining physical activity during refeeding improves body composition, intestinal hyperpermeability and behavior in anorectic mice
title_full Maintaining physical activity during refeeding improves body composition, intestinal hyperpermeability and behavior in anorectic mice
title_fullStr Maintaining physical activity during refeeding improves body composition, intestinal hyperpermeability and behavior in anorectic mice
title_full_unstemmed Maintaining physical activity during refeeding improves body composition, intestinal hyperpermeability and behavior in anorectic mice
title_short Maintaining physical activity during refeeding improves body composition, intestinal hyperpermeability and behavior in anorectic mice
title_sort maintaining physical activity during refeeding improves body composition, intestinal hyperpermeability and behavior in anorectic mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764812/
https://www.ncbi.nlm.nih.gov/pubmed/26906060
http://dx.doi.org/10.1038/srep21887
work_keys_str_mv AT achamrahnajate maintainingphysicalactivityduringrefeedingimprovesbodycompositionintestinalhyperpermeabilityandbehaviorinanorecticmice
AT nobisseverine maintainingphysicalactivityduringrefeedingimprovesbodycompositionintestinalhyperpermeabilityandbehaviorinanorecticmice
AT bretonjonathan maintainingphysicalactivityduringrefeedingimprovesbodycompositionintestinalhyperpermeabilityandbehaviorinanorecticmice
AT jesuspierre maintainingphysicalactivityduringrefeedingimprovesbodycompositionintestinalhyperpermeabilityandbehaviorinanorecticmice
AT belmonteliliana maintainingphysicalactivityduringrefeedingimprovesbodycompositionintestinalhyperpermeabilityandbehaviorinanorecticmice
AT maurerbrigitte maintainingphysicalactivityduringrefeedingimprovesbodycompositionintestinalhyperpermeabilityandbehaviorinanorecticmice
AT legrandromain maintainingphysicalactivityduringrefeedingimprovesbodycompositionintestinalhyperpermeabilityandbehaviorinanorecticmice
AT bolefeysotchristine maintainingphysicalactivityduringrefeedingimprovesbodycompositionintestinalhyperpermeabilityandbehaviorinanorecticmice
AT regojeanlucdo maintainingphysicalactivityduringrefeedingimprovesbodycompositionintestinalhyperpermeabilityandbehaviorinanorecticmice
AT goichonalexis maintainingphysicalactivityduringrefeedingimprovesbodycompositionintestinalhyperpermeabilityandbehaviorinanorecticmice
AT regojeanclaudedo maintainingphysicalactivityduringrefeedingimprovesbodycompositionintestinalhyperpermeabilityandbehaviorinanorecticmice
AT dechelottepierre maintainingphysicalactivityduringrefeedingimprovesbodycompositionintestinalhyperpermeabilityandbehaviorinanorecticmice
AT fetissovsergueio maintainingphysicalactivityduringrefeedingimprovesbodycompositionintestinalhyperpermeabilityandbehaviorinanorecticmice
AT claeyssenssophie maintainingphysicalactivityduringrefeedingimprovesbodycompositionintestinalhyperpermeabilityandbehaviorinanorecticmice
AT coeffiermoise maintainingphysicalactivityduringrefeedingimprovesbodycompositionintestinalhyperpermeabilityandbehaviorinanorecticmice

Ejemplares similares