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Period-independent novel circadian oscillators revealed by timed exercise and palatable meals
The mammalian circadian system is a hierarchical network of oscillators organized to optimally coordinate behavior and physiology with daily environmental cycles. The suprachiasmatic nucleus (SCN) of the hypothalamus is at the top of this hierarchy, synchronizing to the environmental light-dark cycl...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764932/ https://www.ncbi.nlm.nih.gov/pubmed/26904978 http://dx.doi.org/10.1038/srep21945 |
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author | Flôres, Danilo E. F. L. Bettilyon, Crystal N. Yamazaki, Shin |
author_facet | Flôres, Danilo E. F. L. Bettilyon, Crystal N. Yamazaki, Shin |
author_sort | Flôres, Danilo E. F. L. |
collection | PubMed |
description | The mammalian circadian system is a hierarchical network of oscillators organized to optimally coordinate behavior and physiology with daily environmental cycles. The suprachiasmatic nucleus (SCN) of the hypothalamus is at the top of this hierarchy, synchronizing to the environmental light-dark cycle, and coordinates the phases of peripheral clocks. The Period genes are critical components of the molecular timekeeping mechanism of these clocks. Circadian clocks are disabled in Period1/2/3 triple mutant mice, resulting in arrhythmic behavior in constant conditions. We uncovered rhythmic behavior in this mutant by simply exposing the mice to timed access to a palatable meal or running wheel. The emergent circadian behavior rhythms free-ran for many cycles under constant conditions without cyclic environmental cues. Together, these data demonstrate that the palatable meal-inducible circadian oscillator (PICO) and wheel-inducible circadian oscillator (WICO) are generated by non-canonical circadian clocks. Entrainment of these novel oscillators by palatable snacks and timed exercise could become novel therapeutics for human conditions caused by disruptions of the circadian clocks. |
format | Online Article Text |
id | pubmed-4764932 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-47649322016-03-02 Period-independent novel circadian oscillators revealed by timed exercise and palatable meals Flôres, Danilo E. F. L. Bettilyon, Crystal N. Yamazaki, Shin Sci Rep Article The mammalian circadian system is a hierarchical network of oscillators organized to optimally coordinate behavior and physiology with daily environmental cycles. The suprachiasmatic nucleus (SCN) of the hypothalamus is at the top of this hierarchy, synchronizing to the environmental light-dark cycle, and coordinates the phases of peripheral clocks. The Period genes are critical components of the molecular timekeeping mechanism of these clocks. Circadian clocks are disabled in Period1/2/3 triple mutant mice, resulting in arrhythmic behavior in constant conditions. We uncovered rhythmic behavior in this mutant by simply exposing the mice to timed access to a palatable meal or running wheel. The emergent circadian behavior rhythms free-ran for many cycles under constant conditions without cyclic environmental cues. Together, these data demonstrate that the palatable meal-inducible circadian oscillator (PICO) and wheel-inducible circadian oscillator (WICO) are generated by non-canonical circadian clocks. Entrainment of these novel oscillators by palatable snacks and timed exercise could become novel therapeutics for human conditions caused by disruptions of the circadian clocks. Nature Publishing Group 2016-02-24 /pmc/articles/PMC4764932/ /pubmed/26904978 http://dx.doi.org/10.1038/srep21945 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Flôres, Danilo E. F. L. Bettilyon, Crystal N. Yamazaki, Shin Period-independent novel circadian oscillators revealed by timed exercise and palatable meals |
title | Period-independent novel circadian oscillators revealed by timed exercise and palatable meals |
title_full | Period-independent novel circadian oscillators revealed by timed exercise and palatable meals |
title_fullStr | Period-independent novel circadian oscillators revealed by timed exercise and palatable meals |
title_full_unstemmed | Period-independent novel circadian oscillators revealed by timed exercise and palatable meals |
title_short | Period-independent novel circadian oscillators revealed by timed exercise and palatable meals |
title_sort | period-independent novel circadian oscillators revealed by timed exercise and palatable meals |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764932/ https://www.ncbi.nlm.nih.gov/pubmed/26904978 http://dx.doi.org/10.1038/srep21945 |
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