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Period-independent novel circadian oscillators revealed by timed exercise and palatable meals

The mammalian circadian system is a hierarchical network of oscillators organized to optimally coordinate behavior and physiology with daily environmental cycles. The suprachiasmatic nucleus (SCN) of the hypothalamus is at the top of this hierarchy, synchronizing to the environmental light-dark cycl...

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Autores principales: Flôres, Danilo E. F. L., Bettilyon, Crystal N., Yamazaki, Shin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764932/
https://www.ncbi.nlm.nih.gov/pubmed/26904978
http://dx.doi.org/10.1038/srep21945
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author Flôres, Danilo E. F. L.
Bettilyon, Crystal N.
Yamazaki, Shin
author_facet Flôres, Danilo E. F. L.
Bettilyon, Crystal N.
Yamazaki, Shin
author_sort Flôres, Danilo E. F. L.
collection PubMed
description The mammalian circadian system is a hierarchical network of oscillators organized to optimally coordinate behavior and physiology with daily environmental cycles. The suprachiasmatic nucleus (SCN) of the hypothalamus is at the top of this hierarchy, synchronizing to the environmental light-dark cycle, and coordinates the phases of peripheral clocks. The Period genes are critical components of the molecular timekeeping mechanism of these clocks. Circadian clocks are disabled in Period1/2/3 triple mutant mice, resulting in arrhythmic behavior in constant conditions. We uncovered rhythmic behavior in this mutant by simply exposing the mice to timed access to a palatable meal or running wheel. The emergent circadian behavior rhythms free-ran for many cycles under constant conditions without cyclic environmental cues. Together, these data demonstrate that the palatable meal-inducible circadian oscillator (PICO) and wheel-inducible circadian oscillator (WICO) are generated by non-canonical circadian clocks. Entrainment of these novel oscillators by palatable snacks and timed exercise could become novel therapeutics for human conditions caused by disruptions of the circadian clocks.
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spelling pubmed-47649322016-03-02 Period-independent novel circadian oscillators revealed by timed exercise and palatable meals Flôres, Danilo E. F. L. Bettilyon, Crystal N. Yamazaki, Shin Sci Rep Article The mammalian circadian system is a hierarchical network of oscillators organized to optimally coordinate behavior and physiology with daily environmental cycles. The suprachiasmatic nucleus (SCN) of the hypothalamus is at the top of this hierarchy, synchronizing to the environmental light-dark cycle, and coordinates the phases of peripheral clocks. The Period genes are critical components of the molecular timekeeping mechanism of these clocks. Circadian clocks are disabled in Period1/2/3 triple mutant mice, resulting in arrhythmic behavior in constant conditions. We uncovered rhythmic behavior in this mutant by simply exposing the mice to timed access to a palatable meal or running wheel. The emergent circadian behavior rhythms free-ran for many cycles under constant conditions without cyclic environmental cues. Together, these data demonstrate that the palatable meal-inducible circadian oscillator (PICO) and wheel-inducible circadian oscillator (WICO) are generated by non-canonical circadian clocks. Entrainment of these novel oscillators by palatable snacks and timed exercise could become novel therapeutics for human conditions caused by disruptions of the circadian clocks. Nature Publishing Group 2016-02-24 /pmc/articles/PMC4764932/ /pubmed/26904978 http://dx.doi.org/10.1038/srep21945 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Flôres, Danilo E. F. L.
Bettilyon, Crystal N.
Yamazaki, Shin
Period-independent novel circadian oscillators revealed by timed exercise and palatable meals
title Period-independent novel circadian oscillators revealed by timed exercise and palatable meals
title_full Period-independent novel circadian oscillators revealed by timed exercise and palatable meals
title_fullStr Period-independent novel circadian oscillators revealed by timed exercise and palatable meals
title_full_unstemmed Period-independent novel circadian oscillators revealed by timed exercise and palatable meals
title_short Period-independent novel circadian oscillators revealed by timed exercise and palatable meals
title_sort period-independent novel circadian oscillators revealed by timed exercise and palatable meals
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764932/
https://www.ncbi.nlm.nih.gov/pubmed/26904978
http://dx.doi.org/10.1038/srep21945
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