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Physical activity and FTO genotype by physical activity interactive influences on obesity
BACKGROUND: Although the effect of the fat mass and obesity-associated (FTO) gene on adiposity is well established, there is a lack of evidence whether physical activity (PA) modifies the effect of FTO variants on obesity in Latino populations. Therefore, the purpose of this study was to examine PA...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765034/ https://www.ncbi.nlm.nih.gov/pubmed/26908368 http://dx.doi.org/10.1186/s12863-016-0357-6 |
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author | Kim, Joon Young DeMenna, Jacob T. Puppala, Sobha Chittoor, Geetha Schneider, Jennifer Duggirala, Ravindranath Mandarino, Lawrence J. Shaibi, Gabriel Q. Coletta, Dawn K. |
author_facet | Kim, Joon Young DeMenna, Jacob T. Puppala, Sobha Chittoor, Geetha Schneider, Jennifer Duggirala, Ravindranath Mandarino, Lawrence J. Shaibi, Gabriel Q. Coletta, Dawn K. |
author_sort | Kim, Joon Young |
collection | PubMed |
description | BACKGROUND: Although the effect of the fat mass and obesity-associated (FTO) gene on adiposity is well established, there is a lack of evidence whether physical activity (PA) modifies the effect of FTO variants on obesity in Latino populations. Therefore, the purpose of this study was to examine PA influences and interactive effects between FTO variants and PA on measures of adiposity in Latinos. RESULTS: After controlling for age and sex, participants who did not engage in regular PA exhibited higher BMI, fat mass, HC, and WC with statistical significance (P < 0.001). Although significant associations between the three FTO genotypes and adiposity measures were found, none of the FTO genotype by PA interaction assessments revealed nominally significant associations. However, several of such interactive influences exhibited considerable trend towards association. CONCLUSIONS: These data suggest that adiposity measures are associated with PA and FTO variants in Latinos, but the impact of their interactive influences on these obesity measures appear to be minimal. Future studies with large sample sizes may help to determine whether individuals with specific FTO variants exhibit differential responses to PA interventions. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12863-016-0357-6) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4765034 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-47650342016-02-25 Physical activity and FTO genotype by physical activity interactive influences on obesity Kim, Joon Young DeMenna, Jacob T. Puppala, Sobha Chittoor, Geetha Schneider, Jennifer Duggirala, Ravindranath Mandarino, Lawrence J. Shaibi, Gabriel Q. Coletta, Dawn K. BMC Genet Research Article BACKGROUND: Although the effect of the fat mass and obesity-associated (FTO) gene on adiposity is well established, there is a lack of evidence whether physical activity (PA) modifies the effect of FTO variants on obesity in Latino populations. Therefore, the purpose of this study was to examine PA influences and interactive effects between FTO variants and PA on measures of adiposity in Latinos. RESULTS: After controlling for age and sex, participants who did not engage in regular PA exhibited higher BMI, fat mass, HC, and WC with statistical significance (P < 0.001). Although significant associations between the three FTO genotypes and adiposity measures were found, none of the FTO genotype by PA interaction assessments revealed nominally significant associations. However, several of such interactive influences exhibited considerable trend towards association. CONCLUSIONS: These data suggest that adiposity measures are associated with PA and FTO variants in Latinos, but the impact of their interactive influences on these obesity measures appear to be minimal. Future studies with large sample sizes may help to determine whether individuals with specific FTO variants exhibit differential responses to PA interventions. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12863-016-0357-6) contains supplementary material, which is available to authorized users. BioMed Central 2016-02-24 /pmc/articles/PMC4765034/ /pubmed/26908368 http://dx.doi.org/10.1186/s12863-016-0357-6 Text en © Kim et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Kim, Joon Young DeMenna, Jacob T. Puppala, Sobha Chittoor, Geetha Schneider, Jennifer Duggirala, Ravindranath Mandarino, Lawrence J. Shaibi, Gabriel Q. Coletta, Dawn K. Physical activity and FTO genotype by physical activity interactive influences on obesity |
title | Physical activity and FTO genotype by physical activity interactive influences on obesity |
title_full | Physical activity and FTO genotype by physical activity interactive influences on obesity |
title_fullStr | Physical activity and FTO genotype by physical activity interactive influences on obesity |
title_full_unstemmed | Physical activity and FTO genotype by physical activity interactive influences on obesity |
title_short | Physical activity and FTO genotype by physical activity interactive influences on obesity |
title_sort | physical activity and fto genotype by physical activity interactive influences on obesity |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765034/ https://www.ncbi.nlm.nih.gov/pubmed/26908368 http://dx.doi.org/10.1186/s12863-016-0357-6 |
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