Computational prediction and experimental validation of novel Hedgehog-responsive enhancers linked to genes of the Hedgehog pathway

BACKGROUND: The Hedgehog (Hh) signaling pathway, acting through three homologous transcription factors (GLI1, GLI2, GLI3) in vertebrates, plays multiple roles in embryonic organ development and adult tissue homeostasis. At the level of the genome, GLI factors bind to specific motifs in enhancers, so...

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Detalles Bibliográficos
Autores principales: Gurdziel, Katherine, Vogt, Kyle R., Schneider, Gary, Richards, Neil, Gumucio, Deborah L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765071/
https://www.ncbi.nlm.nih.gov/pubmed/26912062
http://dx.doi.org/10.1186/s12861-016-0106-0

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