Pharmacological blockade of aquaporin-1 water channel by AqB013 restricts migration and invasiveness of colon cancer cells and prevents endothelial tube formation in vitro

BACKGROUND: Aquaporins (AQP) are water channel proteins that enable fluid fluxes across cell membranes, important for homeostasis of the tissue environment and for cell migration. AQP1 knockout mouse models of human cancers showed marked inhibition of tumor-induced angiogenesis, and in pre-clinical...

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Detalles Bibliográficos
Autores principales: Dorward, Hilary S., Du, Alice, Bruhn, Maressa A., Wrin, Joseph, Pei, Jinxin V., Evdokiou, Andreas, Price, Timothy J., Yool, Andrea J., Hardingham, Jennifer E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765103/
https://www.ncbi.nlm.nih.gov/pubmed/26912239
http://dx.doi.org/10.1186/s13046-016-0310-6

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