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De novo DNA methylation drives 5hmC accumulation in mouse zygotes

Zygotic epigenetic reprogramming entails genome-wide DNA demethylation that is accompanied by Ten-Eleven Translocation 3 (Tet3)-driven oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC)(1-4). Here we demonstrate using detailed immunofluorescence analysis and ultra-sensitive LC/MS...

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Detalles Bibliográficos
Autores principales:	Amouroux, Rachel, Nashun, Buhe, Shirane, Kenjiro, Nakagawa, Shoma, Hill, Peter WS, D’Souza, Zelpha, Nakayama, Manabu, Matsuda, Masashi, Turp, Aleksandra, Ndjetehe, Elodie, Encheva, Vesela, Kudo, Nobuaki R, Koseki, Haruhiko, Sasaki, Hiroyuki, Hajkova, Petra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765106/ https://www.ncbi.nlm.nih.gov/pubmed/26751286 http://dx.doi.org/10.1038/ncb3296

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