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Rhabdomyolysis after lamotrigine overdose: a case report and review of the literature
BACKGROUND: Lamotrigine is an effective anticonvulsant drug that has also been demonstrated to be effective in the treatment of bipolar disorder. We report a case of rhabdomyolysis after intentional overdose in a woman aged 48. CASE PRESENTATION: A 48-year-old female presented to the emergency depar...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765213/ https://www.ncbi.nlm.nih.gov/pubmed/26913053 http://dx.doi.org/10.1186/s12991-016-0093-3 |
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author | Karaoulanis, Sokratis E. Syngelakis, Markos Fokas, Konstantinos |
author_facet | Karaoulanis, Sokratis E. Syngelakis, Markos Fokas, Konstantinos |
author_sort | Karaoulanis, Sokratis E. |
collection | PubMed |
description | BACKGROUND: Lamotrigine is an effective anticonvulsant drug that has also been demonstrated to be effective in the treatment of bipolar disorder. We report a case of rhabdomyolysis after intentional overdose in a woman aged 48. CASE PRESENTATION: A 48-year-old female presented to the emergency department after an acute ingestion of 6 g of lamotrigine. The patient suffered from bipolar disorder, and she was taking lamotrigine and olanzapine. At that point, she had a major depressive episode, and she wanted to commit suicide. Activated charcoal was administered in the emergency department. Her vital signs were still normal, and she entered the Medical clinic, where she had been there for 2 days in a good condition. The hematological and biochemical results were normal. On the fourth day, the levels of creatine phosphokinase (CPK) showed remarkable increase (2500 IU/ml). Fluid and bicarbonate intravenous administration was performed, and CPK levels returned to normal after 3 days. CONCLUSION: The majority of patients exposed to lamotrigine in overdose experienced no toxic clinical effects. The most common clinical effects are drowsiness and lethargy, vomiting, nausea, ataxia, dizziness/vertigo, and tachycardia. In this case report, the patient was alert and did not have any serious complications, except for mild rhabdomyolysis, which was the main consequence of lamotrigine overdose. |
format | Online Article Text |
id | pubmed-4765213 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-47652132016-02-25 Rhabdomyolysis after lamotrigine overdose: a case report and review of the literature Karaoulanis, Sokratis E. Syngelakis, Markos Fokas, Konstantinos Ann Gen Psychiatry Case Report BACKGROUND: Lamotrigine is an effective anticonvulsant drug that has also been demonstrated to be effective in the treatment of bipolar disorder. We report a case of rhabdomyolysis after intentional overdose in a woman aged 48. CASE PRESENTATION: A 48-year-old female presented to the emergency department after an acute ingestion of 6 g of lamotrigine. The patient suffered from bipolar disorder, and she was taking lamotrigine and olanzapine. At that point, she had a major depressive episode, and she wanted to commit suicide. Activated charcoal was administered in the emergency department. Her vital signs were still normal, and she entered the Medical clinic, where she had been there for 2 days in a good condition. The hematological and biochemical results were normal. On the fourth day, the levels of creatine phosphokinase (CPK) showed remarkable increase (2500 IU/ml). Fluid and bicarbonate intravenous administration was performed, and CPK levels returned to normal after 3 days. CONCLUSION: The majority of patients exposed to lamotrigine in overdose experienced no toxic clinical effects. The most common clinical effects are drowsiness and lethargy, vomiting, nausea, ataxia, dizziness/vertigo, and tachycardia. In this case report, the patient was alert and did not have any serious complications, except for mild rhabdomyolysis, which was the main consequence of lamotrigine overdose. BioMed Central 2016-02-24 /pmc/articles/PMC4765213/ /pubmed/26913053 http://dx.doi.org/10.1186/s12991-016-0093-3 Text en © Karaoulanis et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Case Report Karaoulanis, Sokratis E. Syngelakis, Markos Fokas, Konstantinos Rhabdomyolysis after lamotrigine overdose: a case report and review of the literature |
title | Rhabdomyolysis after lamotrigine overdose: a case report and review of the literature |
title_full | Rhabdomyolysis after lamotrigine overdose: a case report and review of the literature |
title_fullStr | Rhabdomyolysis after lamotrigine overdose: a case report and review of the literature |
title_full_unstemmed | Rhabdomyolysis after lamotrigine overdose: a case report and review of the literature |
title_short | Rhabdomyolysis after lamotrigine overdose: a case report and review of the literature |
title_sort | rhabdomyolysis after lamotrigine overdose: a case report and review of the literature |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765213/ https://www.ncbi.nlm.nih.gov/pubmed/26913053 http://dx.doi.org/10.1186/s12991-016-0093-3 |
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