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Myeloid Derived Suppressor Cells: Fuel the Fire

Low oxygen tension, hypoxia, is a characteristic of many tumors and associated with the poor prognosis. Hypoxia invites bone marrow derived cells (BMDCs) from bone marrow to the site of tumor. These recruited CXCR4+ BMDCs provide favorable environment for the tumor growth by acquiring pro-angiogenic...

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Detalles Bibliográficos
Autores principales: Achyut, B. R., Arbab, Ali S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765500/
https://www.ncbi.nlm.nih.gov/pubmed/26925346
http://dx.doi.org/10.4172/2168-9652.1000e123
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author Achyut, B. R.
Arbab, Ali S.
author_facet Achyut, B. R.
Arbab, Ali S.
author_sort Achyut, B. R.
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description Low oxygen tension, hypoxia, is a characteristic of many tumors and associated with the poor prognosis. Hypoxia invites bone marrow derived cells (BMDCs) from bone marrow to the site of tumor. These recruited CXCR4+ BMDCs provide favorable environment for the tumor growth by acquiring pro-angiogenic phenotype such as CD45+VEGFR2+ Endothelial Progenitor Cells (EPC), or CD45+Tie2+ myeloid cells. CD11b+CD13+ myeloid population of the BMDCs modulate tumor progression. These myeloid populations retain immunosuppressive characteristics, for example, myeloid derived suppressor cells (MDSCs), and regulates immune- suppression by inhibiting cytotoxic T cell function. In addition, MDSCs were observed at the premetastatic niche of the distant organs in other tumors. Protumorigenic and prometastatic role of the myeloid cells provides a basis for therapeutic targeting of immunosuppression and thus inhibiting tumor development and metastasis.
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spelling pubmed-47655002016-02-24 Myeloid Derived Suppressor Cells: Fuel the Fire Achyut, B. R. Arbab, Ali S. Biochem Physiol Article Low oxygen tension, hypoxia, is a characteristic of many tumors and associated with the poor prognosis. Hypoxia invites bone marrow derived cells (BMDCs) from bone marrow to the site of tumor. These recruited CXCR4+ BMDCs provide favorable environment for the tumor growth by acquiring pro-angiogenic phenotype such as CD45+VEGFR2+ Endothelial Progenitor Cells (EPC), or CD45+Tie2+ myeloid cells. CD11b+CD13+ myeloid population of the BMDCs modulate tumor progression. These myeloid populations retain immunosuppressive characteristics, for example, myeloid derived suppressor cells (MDSCs), and regulates immune- suppression by inhibiting cytotoxic T cell function. In addition, MDSCs were observed at the premetastatic niche of the distant organs in other tumors. Protumorigenic and prometastatic role of the myeloid cells provides a basis for therapeutic targeting of immunosuppression and thus inhibiting tumor development and metastasis. 2014-06-23 2014-08 /pmc/articles/PMC4765500/ /pubmed/26925346 http://dx.doi.org/10.4172/2168-9652.1000e123 Text en http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Achyut, B. R.
Arbab, Ali S.
Myeloid Derived Suppressor Cells: Fuel the Fire
title Myeloid Derived Suppressor Cells: Fuel the Fire
title_full Myeloid Derived Suppressor Cells: Fuel the Fire
title_fullStr Myeloid Derived Suppressor Cells: Fuel the Fire
title_full_unstemmed Myeloid Derived Suppressor Cells: Fuel the Fire
title_short Myeloid Derived Suppressor Cells: Fuel the Fire
title_sort myeloid derived suppressor cells: fuel the fire
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765500/
https://www.ncbi.nlm.nih.gov/pubmed/26925346
http://dx.doi.org/10.4172/2168-9652.1000e123
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