Cargando…

Role of Protein Tyrosine Phosphatases in Plants

Reversible protein phosphorylation is a crucial regulatory mechanism that controls many biological processes in eukaryotes. In plants, phosphorylation events primarily occur on serine (Ser) and threonine (Thr) residues, while in certain cases, it was also discovered on tyrosine (Tyr) residues. In co...

Descripción completa

Detalles Bibliográficos
Autores principales: Shankar, Alka, Agrawal, Nisha, Sharma, Manisha, Pandey, Amita, Pandey, Girdhar K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765517/
https://www.ncbi.nlm.nih.gov/pubmed/26962298
http://dx.doi.org/10.2174/1389202916666150424234300
_version_ 1782417554420006912
author Shankar, Alka
Agrawal, Nisha
Sharma, Manisha
Pandey, Amita
Pandey, Girdhar K.
author_facet Shankar, Alka
Agrawal, Nisha
Sharma, Manisha
Pandey, Amita
Pandey, Girdhar K.
author_sort Shankar, Alka
collection PubMed
description Reversible protein phosphorylation is a crucial regulatory mechanism that controls many biological processes in eukaryotes. In plants, phosphorylation events primarily occur on serine (Ser) and threonine (Thr) residues, while in certain cases, it was also discovered on tyrosine (Tyr) residues. In contrary to plants, extensive reports on Tyr phosphorylation regulating a large numbers of biological processes exist in animals. Despite of such prodigious function in animals, Tyr phosphorylation is a least studied mechanism of protein regulation in plants. Recently, various chemical analytical procedures have strengthened the view that Tyr phosphorylation is equally prevalent in plants as in animals. However, regardless of Tyr phosphorylation events occuring in plants, no evidence could be found for the existence of gene encoding for Tyr phosphorylation i.e. the typical Tyr kinases. Various methodologies have suggested that plant responses to stress signals and developmental processes involved modifications in protein Tyr phosphorylation. Correspondingly, various reports have established the role of PTPs (Protein Tyrosine Phosphatases) in the dephosphorylation and inactivation of mitogen activated protein kinases (MAPKs) hence, in the regulation of MAPK signaling cascade. Besides this, many dual specificity protein phosphatases (DSPs) are also known to bind starch and regulate starch metabolism through reversible phosphorylation. Here, we are emphasizing the significant progress on protein Tyr phosphatases to understand the role of these enzymes in the regulation of post-translational modification in plant physiology and development.
format Online
Article
Text
id pubmed-4765517
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Bentham Science Publishers
record_format MEDLINE/PubMed
spelling pubmed-47655172016-03-09 Role of Protein Tyrosine Phosphatases in Plants Shankar, Alka Agrawal, Nisha Sharma, Manisha Pandey, Amita Pandey, Girdhar K. Curr Genomics Article Reversible protein phosphorylation is a crucial regulatory mechanism that controls many biological processes in eukaryotes. In plants, phosphorylation events primarily occur on serine (Ser) and threonine (Thr) residues, while in certain cases, it was also discovered on tyrosine (Tyr) residues. In contrary to plants, extensive reports on Tyr phosphorylation regulating a large numbers of biological processes exist in animals. Despite of such prodigious function in animals, Tyr phosphorylation is a least studied mechanism of protein regulation in plants. Recently, various chemical analytical procedures have strengthened the view that Tyr phosphorylation is equally prevalent in plants as in animals. However, regardless of Tyr phosphorylation events occuring in plants, no evidence could be found for the existence of gene encoding for Tyr phosphorylation i.e. the typical Tyr kinases. Various methodologies have suggested that plant responses to stress signals and developmental processes involved modifications in protein Tyr phosphorylation. Correspondingly, various reports have established the role of PTPs (Protein Tyrosine Phosphatases) in the dephosphorylation and inactivation of mitogen activated protein kinases (MAPKs) hence, in the regulation of MAPK signaling cascade. Besides this, many dual specificity protein phosphatases (DSPs) are also known to bind starch and regulate starch metabolism through reversible phosphorylation. Here, we are emphasizing the significant progress on protein Tyr phosphatases to understand the role of these enzymes in the regulation of post-translational modification in plant physiology and development. Bentham Science Publishers 2015-08 2015-08 /pmc/articles/PMC4765517/ /pubmed/26962298 http://dx.doi.org/10.2174/1389202916666150424234300 Text en ©2015 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/legalcode This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Shankar, Alka
Agrawal, Nisha
Sharma, Manisha
Pandey, Amita
Pandey, Girdhar K.
Role of Protein Tyrosine Phosphatases in Plants
title Role of Protein Tyrosine Phosphatases in Plants
title_full Role of Protein Tyrosine Phosphatases in Plants
title_fullStr Role of Protein Tyrosine Phosphatases in Plants
title_full_unstemmed Role of Protein Tyrosine Phosphatases in Plants
title_short Role of Protein Tyrosine Phosphatases in Plants
title_sort role of protein tyrosine phosphatases in plants
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765517/
https://www.ncbi.nlm.nih.gov/pubmed/26962298
http://dx.doi.org/10.2174/1389202916666150424234300
work_keys_str_mv AT shankaralka roleofproteintyrosinephosphatasesinplants
AT agrawalnisha roleofproteintyrosinephosphatasesinplants
AT sharmamanisha roleofproteintyrosinephosphatasesinplants
AT pandeyamita roleofproteintyrosinephosphatasesinplants
AT pandeygirdhark roleofproteintyrosinephosphatasesinplants