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MicroRNAs and Bone Regeneration

Bone has multiple functions, both morphologically and physiologically, and it frequently features in the pathological condition, including fracture and osteoporosis. For bone regeneration therapy, the regulation of osteoblast differentiation is important. MicroRNA (miRNA)s are short noncoding RNA wh...

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Autores principales: Nakasa, Tomoyuki, Yoshizuka, Masaaki, Andry Usman, Muhammad, Elbadry Mahmoud, Elhussein, Ochi, Mitsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765532/
https://www.ncbi.nlm.nih.gov/pubmed/27019619
http://dx.doi.org/10.2174/1389202916666150817213630
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author Nakasa, Tomoyuki
Yoshizuka, Masaaki
Andry Usman, Muhammad
Elbadry Mahmoud, Elhussein
Ochi, Mitsuo
author_facet Nakasa, Tomoyuki
Yoshizuka, Masaaki
Andry Usman, Muhammad
Elbadry Mahmoud, Elhussein
Ochi, Mitsuo
author_sort Nakasa, Tomoyuki
collection PubMed
description Bone has multiple functions, both morphologically and physiologically, and it frequently features in the pathological condition, including fracture and osteoporosis. For bone regeneration therapy, the regulation of osteoblast differentiation is important. MicroRNA (miRNA)s are short noncoding RNA which regulate gene expression at the post-transcriptional level. MiRNAs play an important role not only in a variety of other cellular processes including differentiation, proliferation, and apoptosis but also in the pathogenesis of human diseases. Recently, miRNAs have been known to participate in osteoblast differentiation by regulating several signaling pathways including transcription factors. New insight into the mechanism during osteogenes is affected by miRNAs has been gained. Moreover, therapeutic trials for bone diseases including osteoporosis, fracture and bone defects targeting miRNAs have been examined in animal models. MiRNA therapy will enable development of a bone regeneration therapy.
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spelling pubmed-47655322016-06-01 MicroRNAs and Bone Regeneration Nakasa, Tomoyuki Yoshizuka, Masaaki Andry Usman, Muhammad Elbadry Mahmoud, Elhussein Ochi, Mitsuo Curr Genomics Article Bone has multiple functions, both morphologically and physiologically, and it frequently features in the pathological condition, including fracture and osteoporosis. For bone regeneration therapy, the regulation of osteoblast differentiation is important. MicroRNA (miRNA)s are short noncoding RNA which regulate gene expression at the post-transcriptional level. MiRNAs play an important role not only in a variety of other cellular processes including differentiation, proliferation, and apoptosis but also in the pathogenesis of human diseases. Recently, miRNAs have been known to participate in osteoblast differentiation by regulating several signaling pathways including transcription factors. New insight into the mechanism during osteogenes is affected by miRNAs has been gained. Moreover, therapeutic trials for bone diseases including osteoporosis, fracture and bone defects targeting miRNAs have been examined in animal models. MiRNA therapy will enable development of a bone regeneration therapy. Bentham Science Publishers 2015-12 2015-12 /pmc/articles/PMC4765532/ /pubmed/27019619 http://dx.doi.org/10.2174/1389202916666150817213630 Text en ©2015 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/legalcode This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Nakasa, Tomoyuki
Yoshizuka, Masaaki
Andry Usman, Muhammad
Elbadry Mahmoud, Elhussein
Ochi, Mitsuo
MicroRNAs and Bone Regeneration
title MicroRNAs and Bone Regeneration
title_full MicroRNAs and Bone Regeneration
title_fullStr MicroRNAs and Bone Regeneration
title_full_unstemmed MicroRNAs and Bone Regeneration
title_short MicroRNAs and Bone Regeneration
title_sort micrornas and bone regeneration
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765532/
https://www.ncbi.nlm.nih.gov/pubmed/27019619
http://dx.doi.org/10.2174/1389202916666150817213630
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