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MicroRNAs and Bone Regeneration
Bone has multiple functions, both morphologically and physiologically, and it frequently features in the pathological condition, including fracture and osteoporosis. For bone regeneration therapy, the regulation of osteoblast differentiation is important. MicroRNA (miRNA)s are short noncoding RNA wh...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bentham Science Publishers
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765532/ https://www.ncbi.nlm.nih.gov/pubmed/27019619 http://dx.doi.org/10.2174/1389202916666150817213630 |
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author | Nakasa, Tomoyuki Yoshizuka, Masaaki Andry Usman, Muhammad Elbadry Mahmoud, Elhussein Ochi, Mitsuo |
author_facet | Nakasa, Tomoyuki Yoshizuka, Masaaki Andry Usman, Muhammad Elbadry Mahmoud, Elhussein Ochi, Mitsuo |
author_sort | Nakasa, Tomoyuki |
collection | PubMed |
description | Bone has multiple functions, both morphologically and physiologically, and it frequently features in the pathological condition, including fracture and osteoporosis. For bone regeneration therapy, the regulation of osteoblast differentiation is important. MicroRNA (miRNA)s are short noncoding RNA which regulate gene expression at the post-transcriptional level. MiRNAs play an important role not only in a variety of other cellular processes including differentiation, proliferation, and apoptosis but also in the pathogenesis of human diseases. Recently, miRNAs have been known to participate in osteoblast differentiation by regulating several signaling pathways including transcription factors. New insight into the mechanism during osteogenes is affected by miRNAs has been gained. Moreover, therapeutic trials for bone diseases including osteoporosis, fracture and bone defects targeting miRNAs have been examined in animal models. MiRNA therapy will enable development of a bone regeneration therapy. |
format | Online Article Text |
id | pubmed-4765532 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Bentham Science Publishers |
record_format | MEDLINE/PubMed |
spelling | pubmed-47655322016-06-01 MicroRNAs and Bone Regeneration Nakasa, Tomoyuki Yoshizuka, Masaaki Andry Usman, Muhammad Elbadry Mahmoud, Elhussein Ochi, Mitsuo Curr Genomics Article Bone has multiple functions, both morphologically and physiologically, and it frequently features in the pathological condition, including fracture and osteoporosis. For bone regeneration therapy, the regulation of osteoblast differentiation is important. MicroRNA (miRNA)s are short noncoding RNA which regulate gene expression at the post-transcriptional level. MiRNAs play an important role not only in a variety of other cellular processes including differentiation, proliferation, and apoptosis but also in the pathogenesis of human diseases. Recently, miRNAs have been known to participate in osteoblast differentiation by regulating several signaling pathways including transcription factors. New insight into the mechanism during osteogenes is affected by miRNAs has been gained. Moreover, therapeutic trials for bone diseases including osteoporosis, fracture and bone defects targeting miRNAs have been examined in animal models. MiRNA therapy will enable development of a bone regeneration therapy. Bentham Science Publishers 2015-12 2015-12 /pmc/articles/PMC4765532/ /pubmed/27019619 http://dx.doi.org/10.2174/1389202916666150817213630 Text en ©2015 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/legalcode This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited. |
spellingShingle | Article Nakasa, Tomoyuki Yoshizuka, Masaaki Andry Usman, Muhammad Elbadry Mahmoud, Elhussein Ochi, Mitsuo MicroRNAs and Bone Regeneration |
title | MicroRNAs and Bone Regeneration |
title_full | MicroRNAs and Bone Regeneration |
title_fullStr | MicroRNAs and Bone Regeneration |
title_full_unstemmed | MicroRNAs and Bone Regeneration |
title_short | MicroRNAs and Bone Regeneration |
title_sort | micrornas and bone regeneration |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765532/ https://www.ncbi.nlm.nih.gov/pubmed/27019619 http://dx.doi.org/10.2174/1389202916666150817213630 |
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