Cargando…

Protease inhibitor monotherapy for long-term management of HIV infection: a randomised, controlled, open-label, non-inferiority trial

BACKGROUND: Standard-of-care antiretroviral therapy (ART) uses a combination of drugs deemed essential to minimise treatment failure and drug resistance. Protease inhibitors are potent, with a high genetic barrier to resistance, and have potential use as monotherapy after viral load suppression is a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Paton, Nicholas I, Stöhr, Wolfgang, Arenas-Pinto, Alejandro, Fisher, Martin, Williams, Ian, Johnson, Margaret, Orkin, Chloe, Chen, Fabian, Lee, Vincent, Winston, Alan, Gompels, Mark, Fox, Julie, Scott, Karen, Dunn, David T
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier B.V 2015
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765553/ https://www.ncbi.nlm.nih.gov/pubmed/26423649 http://dx.doi.org/10.1016/S2352-3018(15)00176-9

Ejemplares similares

Next generation sequencing of HIV-1 protease in the PIVOT trial of protease inhibitor monotherapy
por: Dunn, David T., et al.
Publicado: (2018)

Cost-effectiveness analysis of protease inhibitor monotherapy vs. ongoing triple-therapy in the long-term management of HIV patients
por: Oddershede, Lars, et al.
Publicado: (2014)

Neurocognitive Function in HIV Infected Patients on Antiretroviral Therapy
por: Winston, Alan, et al.
Publicado: (2013)

Neurocognitive Function in HIV-Infected Patients: Comparison of Two Methods to Define Impairment
por: Arenas-Pinto, Alejandro, et al.
Publicado: (2014)

Systemic inflammation and residual viraemia in HIV-positive adults on protease inhibitor monotherapy: a cross-sectional study
por: Arenas-Pinto, Alejandro, et al.
Publicado: (2015)

Efficacy of PI monotherapy versus triple therapy for 1964 patients in 10 randomised trials
por: Arribas, Jose, et al.
Publicado: (2014)

A phase IV randomised, open-label pilot study to evaluate switching from protease-inhibitor based regimen to Bictegravir/Emtricitabine/Tenofovir Alafenamide single tablet regimen in Integrase inhibitor-naïve, virologically suppressed HIV-1 infected adults harbouring drug resistance mutations (PIBIK study): study protocol for a randomised trial
por: Iwuji, Collins C., et al.
Publicado: (2020)

Gag-Protease Sequence Evolution Following Protease Inhibitor Monotherapy Treatment Failure in HIV-1 Viruses Circulating in East Africa
por: Sutherland, Katherine A., et al.
Publicado: (2015)

Hepmarc: A 96 week randomised controlled feasibility trial of add-on maraviroc in people with HIV and non-alcoholic fatty liver disease
por: Bradshaw, Daniel, et al.
Publicado: (2023)

Virological outcomes of boosted protease inhibitor-based first-line ART in subjects harbouring thymidine analogue-associated mutations as the sole form of transmitted drug resistance
por: Geretti, Anna Maria, et al.
Publicado: (2019)

Rivaroxaban Monotherapy in Patients with Pulmonary Embolism: Off-Label vs. Labeled Therapy
por: Di Micco, Pierpaolo, et al.
Publicado: (2022)

554. Does Protease Inhibitor (PI) Monotherapy Select Primary PI Resistance?
por: Saling, Christopher, et al.
Publicado: (2018)

Impact of late diagnosis and treatment on life expectancy in people with HIV-1: UK Collaborative HIV Cohort (UK CHIC) Study
por: May, Margaret, et al.
Publicado: (2011)

Agomelatine as monotherapy for major depression: an outpatient, open-label study
por: Pecenak, Jan, et al.
Publicado: (2013)

Effectiveness of Ritonavir-Boosted Protease Inhibitor Monotherapy in Clinical Practice Even with Previous Virological Failures to Protease Inhibitor-Based Regimens
por: López-Cortés, Luis F., et al.
Publicado: (2016)

Evidence for Reduced Drug Susceptibility without Emergence of Major Protease Mutations following Protease Inhibitor Monotherapy Failure in the SARA Trial
por: Sutherland, Katherine A., et al.
Publicado: (2015)

Neurocognitive Impairment in Patients Treated with Protease Inhibitor Monotherapy or Triple Drug Antiretroviral Therapy
por: Pérez-Valero, Ignacio, et al.
Publicado: (2013)

HIV-1 subtype influences susceptibility and response to monotherapy with the protease inhibitor lopinavir/ritonavir
por: Sutherland, K. A., et al.
Publicado: (2015)

Ziconotide Monotherapy: A Systematic Review of Randomised Controlled Trials
por: Brookes, Morag E., et al.
Publicado: (2017)

Correction: Evidence for Reduced Drug Susceptibility without Emergence of Major Protease Mutations following Protease Inhibitor Monotherapy Failure in the SARA Trial
por: Sutherland, Katherine A., et al.
Publicado: (2016)

Agomelatine as monotherapy for major depression: an outpatient, open-label study [Corrigendum]
Publicado: (2013)

Telemedical support for prehospital emergency medical service in severe emergencies: an open-label randomised non-inferiority clinical trial
por: Kowark, Ana, et al.
Publicado: (2023)

Effectiveness of Protease Inhibitor Monotherapy versus Combination Antiretroviral Maintenance Therapy: A Meta-Analysis
por: Mathis, Sandra, et al.
Publicado: (2011)

Protease inhibitor monotherapy is associated with a higher level of monocyte activation, bacterial translocation and inflammation
por: Torres, Berta, et al.
Publicado: (2014)

Exploiting protease activation for therapy
por: Bleuez, Chloe, et al.
Publicado: (2022)

Lipid-Lowering Efficacy of Combination Therapy With Moderate-Intensity Statin and Ezetimibe Versus High-Intensity Statin Monotherapy: A Randomized, Open-Label, Non-Inferiority Trial From Korea
por: Choi, Hyejung, et al.
Publicado: (2023)

Alternative to prophylactic antibiotics for the treatment of recurrent urinary tract infections in women: multicentre, open label, randomised, non-inferiority trial
por: Harding, Chris, et al.
Publicado: (2022)

Eculizumab monotherapy for NMOSD: Data from PREVENT and its open-label extension
por: Pittock, Sean J, et al.
Publicado: (2021)

Resistance mutations in protease gene at baseline are not related to virological failure in patients treated with darunavir/ritonavir monotherapy
por: Gutierrez-Liarte, Angela, et al.
Publicado: (2014)

Impact of tocilizumab monotherapy on patient-reported outcomes in patients with rheumatoid arthritis from two randomised controlled trials
por: Strand, Vibeke, et al.
Publicado: (2017)

Oral-only antibiotics for bone and joint infections in children: study protocol for a nationwide randomised open-label non-inferiority trial
por: Bybeck Nielsen, Allan, et al.
Publicado: (2023)

A multicentre, randomised, non-inferiority clinical trial comparing a nifurtimox-eflornithine combination to standard eflornithine monotherapy for late stage Trypanosoma brucei gambiense human African trypanosomiasis in Uganda
por: Kansiime, Freddie, et al.
Publicado: (2018)

Identification of Protease Specificity Using Biotin-Labeled Substrates
por: Yamamoto, Hiroyuki, et al.
Publicado: (2017)

Retroviral proteases
por: Dunn, Ben M, et al.
Publicado: (2002)

Evaluation of perampanel as monotherapy for focal seizures: Experience from open-label extension studies
por: Kwan, Patrick, et al.
Publicado: (2017)

Phenotypic characterization of virological failure following lopinavir/ritonavir monotherapy using full-length gag–protease genes
por: Sutherland, Katherine A., et al.
Publicado: (2014)

Immunogenicity and safety of one-dose human papillomavirus vaccine compared with two or three doses in Tanzanian girls (DoRIS): an open-label, randomised, non-inferiority trial
por: Watson-Jones, Deborah, et al.
Publicado: (2022)

An analysis of baseline data from the PROUD study: an open-label randomised trial of pre-exposure prophylaxis
por: Dolling, David I., et al.
Publicado: (2016)

Switching from a ritonavir-boosted protease inhibitor to a dolutegravir-based regimen for maintenance of HIV viral suppression in patients with high cardiovascular risk
por: Gatell, José M., et al.
Publicado: (2017)

Impact on life expectancy of HIV-1 positive individuals of CD4(+) cell count and viral load response to antiretroviral therapy
por: May, Margaret T., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_lk03c6tkkra4kdusjb27n6slrl