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Impact of mechanical stretch on the cell behaviors of bone and surrounding tissues
Mechanical loading is recognized to play an important role in regulating the behaviors of cells in bone and surrounding tissues in vivo. Many in vitro studies have been conducted to determine the effects of mechanical loading on individual cell types of the tissues. In this review, we focus specific...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765821/ https://www.ncbi.nlm.nih.gov/pubmed/26977284 http://dx.doi.org/10.1177/2041731415618342 |
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author | Yu, Hye-Sun Kim, Jung-Ju Kim, Hae-Won Lewis, Mark P Wall, Ivan |
author_facet | Yu, Hye-Sun Kim, Jung-Ju Kim, Hae-Won Lewis, Mark P Wall, Ivan |
author_sort | Yu, Hye-Sun |
collection | PubMed |
description | Mechanical loading is recognized to play an important role in regulating the behaviors of cells in bone and surrounding tissues in vivo. Many in vitro studies have been conducted to determine the effects of mechanical loading on individual cell types of the tissues. In this review, we focus specifically on the use of the Flexercell system as a tool for studying cellular responses to mechanical stretch. We assess the literature describing the impact of mechanical stretch on different cell types from bone, muscle, tendon, ligament, and cartilage, describing individual cell phenotype responses. In addition, we review evidence regarding the mechanotransduction pathways that are activated to potentiate these phenotype responses in different cell populations. |
format | Online Article Text |
id | pubmed-4765821 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-47658212016-03-14 Impact of mechanical stretch on the cell behaviors of bone and surrounding tissues Yu, Hye-Sun Kim, Jung-Ju Kim, Hae-Won Lewis, Mark P Wall, Ivan J Tissue Eng Review Mechanical loading is recognized to play an important role in regulating the behaviors of cells in bone and surrounding tissues in vivo. Many in vitro studies have been conducted to determine the effects of mechanical loading on individual cell types of the tissues. In this review, we focus specifically on the use of the Flexercell system as a tool for studying cellular responses to mechanical stretch. We assess the literature describing the impact of mechanical stretch on different cell types from bone, muscle, tendon, ligament, and cartilage, describing individual cell phenotype responses. In addition, we review evidence regarding the mechanotransduction pathways that are activated to potentiate these phenotype responses in different cell populations. SAGE Publications 2016-02-18 /pmc/articles/PMC4765821/ /pubmed/26977284 http://dx.doi.org/10.1177/2041731415618342 Text en © The Author(s) 2016 https://creativecommons.org/licenses/by-nc/3.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Review Yu, Hye-Sun Kim, Jung-Ju Kim, Hae-Won Lewis, Mark P Wall, Ivan Impact of mechanical stretch on the cell behaviors of bone and surrounding tissues |
title | Impact of mechanical stretch on the cell behaviors of bone and
surrounding tissues |
title_full | Impact of mechanical stretch on the cell behaviors of bone and
surrounding tissues |
title_fullStr | Impact of mechanical stretch on the cell behaviors of bone and
surrounding tissues |
title_full_unstemmed | Impact of mechanical stretch on the cell behaviors of bone and
surrounding tissues |
title_short | Impact of mechanical stretch on the cell behaviors of bone and
surrounding tissues |
title_sort | impact of mechanical stretch on the cell behaviors of bone and
surrounding tissues |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765821/ https://www.ncbi.nlm.nih.gov/pubmed/26977284 http://dx.doi.org/10.1177/2041731415618342 |
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