Open Sesame: treasure in store-operated calcium entry pathway for cancer therapy

Store-operated Ca(2+) entry (SOCE) controls intracellular Ca(2+) homeostasis and regulates a wide range of cellular events including proliferation, migration and invasion. The discovery of STIM proteins as Ca(2+) sensors and Orai proteins as Ca(2+) channel pore forming units provided molecular tools...

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Detalles Bibliográficos
Autores principales: Zui, PAN, JianJie, MA
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765918/
https://www.ncbi.nlm.nih.gov/pubmed/25481035
http://dx.doi.org/10.1007/s11427-014-4774-3
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author Zui, PAN
JianJie, MA
author_facet Zui, PAN
JianJie, MA
author_sort Zui, PAN
collection PubMed
description Store-operated Ca(2+) entry (SOCE) controls intracellular Ca(2+) homeostasis and regulates a wide range of cellular events including proliferation, migration and invasion. The discovery of STIM proteins as Ca(2+) sensors and Orai proteins as Ca(2+) channel pore forming units provided molecular tools to understand the physiological function of SOCE. Many studies have revealed the pathophysiological roles of Orai and STIM in tumor cells. This review focuses on recent advances in SOCE and its contribution to tumorigenesis. Altered Orai and/or STIM functions may serve as biomarkers for cancer prognosis, and targeting the SOCE pathway may provide a novel means for cancer treatment.
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spelling pubmed-47659182016-02-24 Open Sesame: treasure in store-operated calcium entry pathway for cancer therapy Zui, PAN JianJie, MA Sci China Life Sci Article Store-operated Ca(2+) entry (SOCE) controls intracellular Ca(2+) homeostasis and regulates a wide range of cellular events including proliferation, migration and invasion. The discovery of STIM proteins as Ca(2+) sensors and Orai proteins as Ca(2+) channel pore forming units provided molecular tools to understand the physiological function of SOCE. Many studies have revealed the pathophysiological roles of Orai and STIM in tumor cells. This review focuses on recent advances in SOCE and its contribution to tumorigenesis. Altered Orai and/or STIM functions may serve as biomarkers for cancer prognosis, and targeting the SOCE pathway may provide a novel means for cancer treatment. 2014-12-07 2015-01 /pmc/articles/PMC4765918/ /pubmed/25481035 http://dx.doi.org/10.1007/s11427-014-4774-3 Text en http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Article
Zui, PAN
JianJie, MA
Open Sesame: treasure in store-operated calcium entry pathway for cancer therapy
title Open Sesame: treasure in store-operated calcium entry pathway for cancer therapy
title_full Open Sesame: treasure in store-operated calcium entry pathway for cancer therapy
title_fullStr Open Sesame: treasure in store-operated calcium entry pathway for cancer therapy
title_full_unstemmed Open Sesame: treasure in store-operated calcium entry pathway for cancer therapy
title_short Open Sesame: treasure in store-operated calcium entry pathway for cancer therapy
title_sort open sesame: treasure in store-operated calcium entry pathway for cancer therapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765918/
https://www.ncbi.nlm.nih.gov/pubmed/25481035
http://dx.doi.org/10.1007/s11427-014-4774-3
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