Structural Basis for Xenon Inhibition in a Cationic Pentameric Ligand-Gated Ion Channel

GLIC receptor is a bacterial pentameric ligand-gated ion channel whose action is inhibited by xenon. Xenon has been used in clinical practice as a potent gaseous anaesthetic for decades, but the molecular mechanism of interactions with its integral membrane receptor targets remains poorly understood...

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Detalles Bibliográficos
Autores principales: Sauguet, Ludovic, Fourati, Zeineb, Prangé, Thierry, Delarue, Marc, Colloc'h, Nathalie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765991/
https://www.ncbi.nlm.nih.gov/pubmed/26910105
http://dx.doi.org/10.1371/journal.pone.0149795

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