Cargando…

Structures of Two Melanoma-Associated Antigens Suggest Allosteric Regulation of Effector Binding

The MAGE (melanoma associated antigen) protein family are tumour-associated proteins normally present only in reproductive tissues such as germ cells of the testis. The human genome encodes over 60 MAGE genes of which one class (containing MAGE-A3 and MAGE-A4) are exclusively expressed in tumours, m...

Descripción completa

Detalles Bibliográficos
Autores principales:	Newman, Joseph A., Cooper, Christopher D. O., Roos, Anette K., Aitkenhead, Hazel, Oppermann, Udo C. T., Cho, Hearn J., Osman, Roman, Gileadi, Opher
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766014/ https://www.ncbi.nlm.nih.gov/pubmed/26910052 http://dx.doi.org/10.1371/journal.pone.0148762

Ejemplares similares

Structures of the Ets Protein DNA-binding Domains of Transcription Factors Etv1, Etv4, Etv5, and Fev: DETERMINANTS OF DNA BINDING AND REDOX REGULATION BY DISULFIDE BOND FORMATION
por: Cooper, Christopher D. O., et al.
Publicado: (2015)

Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway
por: Newman, Joseph A., et al.
Publicado: (2015)

Structural Insights into the Autoregulation and Cooperativity of the Human Transcription Factor Ets-2
por: Newman, Joseph A, et al.
Publicado: (2015)

Insights into the RecQ helicase mechanism revealed by the structure of the helicase domain of human RECQL5
por: Newman, Joseph A., et al.
Publicado: (2017)

A Ubiquitin-Binding Domain that Binds a Structural Fold Distinct from that of Ubiquitin
por: Lim, Michael, et al.
Publicado: (2019)

The crystal structure of human forkhead box N1 in complex with DNA reveals the structural basis for forkhead box family specificity
por: Newman, Joseph A., et al.
Publicado: (2020)

Crystal structures of human soluble guanylate cyclase catalytic domains: promiscuity of the dimer interface and a potential allosteric site
por: Gileadi, Opher, et al.
Publicado: (2013)

Recent advances in the structural molecular biology of Ets transcription factors: interactions, interfaces and inhibition
por: Cooper, Christopher D.O., et al.
Publicado: (2014)

RecQ helicases in DNA repair and cancer targets
por: Newman, Joseph A., et al.
Publicado: (2020)

Structures of soluble guanylate cyclase: implications for regulatory mechanisms and drug development
por: Gileadi, Opher
Publicado: (2014)

Structural basis of fumarate hydratase deficiency
por: Picaud, Sarah, et al.
Publicado: (2011)

Discovery of High-Affinity Noncovalent Allosteric KRAS Inhibitors That Disrupt Effector Binding
por: McCarthy, Michael J., et al.
Publicado: (2019)

Modulation of hemoglobin dynamics by an allosteric effector
por: Lal, Jyotsana, et al.
Publicado: (2017)

Antigen binding allosterically promotes Fc receptor recognition
por: Zhao, Jun, et al.
Publicado: (2018)

Allosteric Control of Ligand Binding Affinity Using Engineered Conformation-Specific Effector Proteins
por: Rizk, Shahir S., et al.
Publicado: (2011)

A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family
por: Baddock, Hannah T, et al.
Publicado: (2021)

Cyclic-di-GMP and ADP bind to separate domains of PilB as mutual allosteric effectors
por: Dye, Keane J., et al.
Publicado: (2020)

Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair
por: Vaz, Bruno, et al.
Publicado: (2016)

Thrombin A-Chain: Activation Remnant or Allosteric Effector?
por: Carter, Isis S. R., et al.
Publicado: (2010)

Mutational mimics of allosteric effectors: a genome editing design to validate allosteric drug targets
por: Tang, Qingling, et al.
Publicado: (2019)

AlloSigMA 2: paving the way to designing allosteric effectors and to exploring allosteric effects of mutations
por: Tan, Zhen Wah, et al.
Publicado: (2020)

Novel Allosteric Effectors Targeting Human Transcription Factor TEAD
por: Ibrahim, Mayar Tarek, et al.
Publicado: (2023)

Antibody-protein binding and conformational changes: identifying allosteric signalling pathways to engineer a better effector response
por: Al Qaraghuli, Mohammed M., et al.
Publicado: (2020)

Discovery of Novel Allosteric Effectors Based on the Predicted Allosteric Sites for Escherichia coli D-3-Phosphoglycerate Dehydrogenase
por: Wang, Qian, et al.
Publicado: (2014)

Crystal Structures of the Catalytic Domain of Human Soluble Guanylate Cyclase
por: Allerston, Charles K., et al.
Publicado: (2013)

The SNM1A DNA repair nuclease
por: Baddock, Hannah T., et al.
Publicado: (2020)

Melanoma antigen-specific effector T cell cytokine secretion patterns in patients treated with ipilimumab
por: Najjar, Yana G., et al.
Publicado: (2017)

The scientific impact of the Structural Genomics Consortium: a protein family and ligand-centered approach to medically-relevant human proteins
por: Gileadi, Opher, et al.
Publicado: (2007)

The roles of Jumonji-type oxygenases in human disease
por: Johansson, Catrine, et al.
Publicado: (2014)

Cysteine modifiers suggest an allosteric inhibitory site on the CAL PDZ domain
por: Zhao, Yu, et al.
Publicado: (2018)

The structures of the SNM1A and SNM1B/Apollo nuclease domains reveal a potential basis for their distinct DNA processing activities
por: Allerston, Charles K., et al.
Publicado: (2015)

Structural Analysis of Inhibitor Binding to CAMKK1 Identifies Features Necessary for Design of Specific Inhibitors
por: Santiago, André da Silva, et al.
Publicado: (2018)

Broad-Spectrum Allosteric Inhibition of Herpesvirus Proteases
por: Gable, Jonathan E., et al.
Publicado: (2014)

Dimeric Structure of the Pseudokinase IRAK3 Suggests an Allosteric Mechanism for Negative Regulation
por: Lange, Sven M., et al.
Publicado: (2021)

Convergent Transmission of RNAi Guide-Target Mismatch Information across Argonaute Internal Allosteric Network
por: Joseph, Thomas T., et al.
Publicado: (2012)

In Silico Prediction and Validation of CB2 Allosteric Binding Sites to Aid the Design of Allosteric Modulators
por: Yuan, Jiayi, et al.
Publicado: (2022)

Combined endogenous MR biomarkers to assess changes in tumor oxygenation induced by an allosteric effector of hemoglobin
por: Cao‐Pham, Thanh‐Trang, et al.
Publicado: (2019)

Effector-dependent structural transformation of a crystalline framework with allosteric effects on molecular recognition ability
por: Hayashi, Ryunosuke, et al.
Publicado: (2023)

Allosterically Linked Binding Sites in Serotonin Transporter Revealed by Single Molecule Force Spectroscopy
por: Zhu, Rong, et al.
Publicado: (2020)

High-throughput production of human proteins for crystallization: The SGC experience
por: Savitsky, Pavel, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_j655qen9c26mmgp66ecc236k0d