Polymorphisms in the TMEM132D region are associated with panic disorder in HLA-DRB1*13:02-negative individuals of a Japanese population

We herein report an association between TMEM132D and panic disorder (PD) in a Japanese population, evaluating the effects of HLA-DRB1*13:02, which we previously reported as a susceptibility genetic factor for PD. SNPs in TMEM132D showed significant associations with PD in subjects without HLA-DRB1*1...

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Detalles Bibliográficos
Autores principales: Shimada-Sugimoto, Mihoko, Otowa, Takeshi, Miyagawa, Taku, Khor, Seik-Soon, Omae, Yosuke, Toyo-oka, Licht, Sugaya, Nagisa, Kawamura, Yoshiya, Umekage, Tadashi, Miyashita, Akinori, Kuwano, Ryozo, Kaiya, Hisanobu, Kasai, Kiyoto, Tanii, Hisashi, Okazaki, Yuji, Tokunaga, Katsushi, Sasaki, Tsukasa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Data Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766370/
https://www.ncbi.nlm.nih.gov/pubmed/27081567
http://dx.doi.org/10.1038/hgv.2016.1
Descripción
Sumario:We herein report an association between TMEM132D and panic disorder (PD) in a Japanese population, evaluating the effects of HLA-DRB1*13:02, which we previously reported as a susceptibility genetic factor for PD. SNPs in TMEM132D showed significant associations with PD in subjects without HLA-DRB1*13:02 (rs4759997; P=5.02×10(−6), odds ratio=1.50) but not in those with the HLA allele. TMEM132D might have a role in the development of PD in subjects without HLA-DRB1*13:02.

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