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Polymorphisms in the TMEM132D region are associated with panic disorder in HLA-DRB1*13:02-negative individuals of a Japanese population
We herein report an association between TMEM132D and panic disorder (PD) in a Japanese population, evaluating the effects of HLA-DRB1*13:02, which we previously reported as a susceptibility genetic factor for PD. SNPs in TMEM132D showed significant associations with PD in subjects without HLA-DRB1*1...
| Autores principales: | , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766370/ https://www.ncbi.nlm.nih.gov/pubmed/27081567 http://dx.doi.org/10.1038/hgv.2016.1 |
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| author | Shimada-Sugimoto, Mihoko Otowa, Takeshi Miyagawa, Taku Khor, Seik-Soon Omae, Yosuke Toyo-oka, Licht Sugaya, Nagisa Kawamura, Yoshiya Umekage, Tadashi Miyashita, Akinori Kuwano, Ryozo Kaiya, Hisanobu Kasai, Kiyoto Tanii, Hisashi Okazaki, Yuji Tokunaga, Katsushi Sasaki, Tsukasa |
| author_facet | Shimada-Sugimoto, Mihoko Otowa, Takeshi Miyagawa, Taku Khor, Seik-Soon Omae, Yosuke Toyo-oka, Licht Sugaya, Nagisa Kawamura, Yoshiya Umekage, Tadashi Miyashita, Akinori Kuwano, Ryozo Kaiya, Hisanobu Kasai, Kiyoto Tanii, Hisashi Okazaki, Yuji Tokunaga, Katsushi Sasaki, Tsukasa |
| author_sort | Shimada-Sugimoto, Mihoko |
| collection | PubMed |
| description | We herein report an association between TMEM132D and panic disorder (PD) in a Japanese population, evaluating the effects of HLA-DRB1*13:02, which we previously reported as a susceptibility genetic factor for PD. SNPs in TMEM132D showed significant associations with PD in subjects without HLA-DRB1*13:02 (rs4759997; P=5.02×10(−6), odds ratio=1.50) but not in those with the HLA allele. TMEM132D might have a role in the development of PD in subjects without HLA-DRB1*13:02. |
| format | Online Article Text |
| id | pubmed-4766370 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2016 |
| publisher | Nature Publishing Group |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-47663702016-04-14 Polymorphisms in the TMEM132D region are associated with panic disorder in HLA-DRB1*13:02-negative individuals of a Japanese population Shimada-Sugimoto, Mihoko Otowa, Takeshi Miyagawa, Taku Khor, Seik-Soon Omae, Yosuke Toyo-oka, Licht Sugaya, Nagisa Kawamura, Yoshiya Umekage, Tadashi Miyashita, Akinori Kuwano, Ryozo Kaiya, Hisanobu Kasai, Kiyoto Tanii, Hisashi Okazaki, Yuji Tokunaga, Katsushi Sasaki, Tsukasa Hum Genome Var Data Report We herein report an association between TMEM132D and panic disorder (PD) in a Japanese population, evaluating the effects of HLA-DRB1*13:02, which we previously reported as a susceptibility genetic factor for PD. SNPs in TMEM132D showed significant associations with PD in subjects without HLA-DRB1*13:02 (rs4759997; P=5.02×10(−6), odds ratio=1.50) but not in those with the HLA allele. TMEM132D might have a role in the development of PD in subjects without HLA-DRB1*13:02. Nature Publishing Group 2016-02-25 /pmc/articles/PMC4766370/ /pubmed/27081567 http://dx.doi.org/10.1038/hgv.2016.1 Text en Copyright © 2016 Official journal of the Japan Society of Human Genetics http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| spellingShingle | Data Report Shimada-Sugimoto, Mihoko Otowa, Takeshi Miyagawa, Taku Khor, Seik-Soon Omae, Yosuke Toyo-oka, Licht Sugaya, Nagisa Kawamura, Yoshiya Umekage, Tadashi Miyashita, Akinori Kuwano, Ryozo Kaiya, Hisanobu Kasai, Kiyoto Tanii, Hisashi Okazaki, Yuji Tokunaga, Katsushi Sasaki, Tsukasa Polymorphisms in the TMEM132D region are associated with panic disorder in HLA-DRB1*13:02-negative individuals of a Japanese population |
| title | Polymorphisms in the TMEM132D region are associated with panic disorder in HLA-DRB1*13:02-negative individuals of a Japanese population |
| title_full | Polymorphisms in the TMEM132D region are associated with panic disorder in HLA-DRB1*13:02-negative individuals of a Japanese population |
| title_fullStr | Polymorphisms in the TMEM132D region are associated with panic disorder in HLA-DRB1*13:02-negative individuals of a Japanese population |
| title_full_unstemmed | Polymorphisms in the TMEM132D region are associated with panic disorder in HLA-DRB1*13:02-negative individuals of a Japanese population |
| title_short | Polymorphisms in the TMEM132D region are associated with panic disorder in HLA-DRB1*13:02-negative individuals of a Japanese population |
| title_sort | polymorphisms in the tmem132d region are associated with panic disorder in hla-drb1*13:02-negative individuals of a japanese population |
| topic | Data Report |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766370/ https://www.ncbi.nlm.nih.gov/pubmed/27081567 http://dx.doi.org/10.1038/hgv.2016.1 |
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