CYP46A1, the rate-limiting enzyme for cholesterol degradation, is neuroprotective in Huntington’s disease

Huntington’s disease is an autosomal dominant neurodegenerative disease caused by abnormal polyglutamine expansion in huntingtin (Exp-HTT) leading to degeneration of striatal neurons. Altered brain cholesterol homeostasis has been implicated in Huntington’s disease, with increased accumulation of ch...

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Detalles Bibliográficos
Autores principales: Boussicault, Lydie, Alves, Sandro, Lamazière, Antonin, Planques, Anabelle, Heck, Nicolas, Moumné, Lara, Despres, Gaëtan, Bolte, Susanne, Hu, Amélie, Pagès, Christiane, Galvan, Laurie, Piguet, Francoise, Aubourg, Patrick, Cartier, Nathalie, Caboche, Jocelyne, Betuing, Sandrine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766376/
https://www.ncbi.nlm.nih.gov/pubmed/26912634
http://dx.doi.org/10.1093/brain/awv384

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