Rational design and validation of an anti-protein kinase C active-state specific antibody based on conformational changes

Protein kinase C (PKC) plays a regulatory role in key pathways in cancer. However, since phosphorylation is a step for classical PKC (cPKC) maturation and does not correlate with activation, there is a lack of tools to detect active PKC in tissue samples. Here, a structure-based rational approach wa...

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Detalles Bibliográficos
Autores principales: Pena, Darlene Aparecida, Andrade, Victor Piana de, Silva, Gabriela Ávila Fernandes, Neves, José Ivanildo, Oliveira, Paulo Sergio Lopes de, Alves, Maria Julia Manso, Devi, Lakshmi A., Schechtman, Deborah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766434/
https://www.ncbi.nlm.nih.gov/pubmed/26911897
http://dx.doi.org/10.1038/srep22114

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