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Discovery of novel PDE9 inhibitors capable of inhibiting Aβ aggregation as potential candidates for the treatment of Alzheimer’s disease

Recently, phosphodiesterase-9 (PDE9) inhibitors and biometal-chelators have received much attention as potential therapeutics for the treatment of Alzheimer’s disease (AD). Here, we designed, synthesized, and evaluated a novel series of PDE9 inhibitors with the ability to chelate metal ions. The bio...

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Detalles Bibliográficos
Autores principales:	Su, Tao, Zhang, Tianhua, Xie, Shishun, Yan, Jun, Wu, Yinuo, Li, Xingshu, Huang, Ling, Luo, Hai-Bin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766439/ https://www.ncbi.nlm.nih.gov/pubmed/26911795 http://dx.doi.org/10.1038/srep21826

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