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Epigenetic Silencing of the Key Antioxidant Enzyme Catalase in Karyotypically Abnormal Human Pluripotent Stem Cells

Epigenomic regulation is likely to be important in the maintenance of genomic integrity of human pluripotent stem cells, however, the mechanisms are unknown. We explored the epigenomes and transcriptomes of human pluripotent stem cells before and after spontaneous transformation to abnormal karyotyp...

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Detalles Bibliográficos
Autores principales:	Konki, Mikko, Pasumarthy, Kalyan, Malonzo, Maia, Sainio, Annele, Valensisi, Cristina, Söderström, Mirva, Emani, Maheswara Reddy, Stubb, Aki, Närvä, Elisa, Ghimire, Bishwa, Laiho, Asta, Järveläinen, Hannu, Lahesmaa, Riitta, Lähdesmäki, Harri, Hawkins, R. David, Lund, Riikka J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766493/ https://www.ncbi.nlm.nih.gov/pubmed/26911679 http://dx.doi.org/10.1038/srep22190

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