Pharmacological BACE1 and BACE2 inhibition induces hair depigmentation by inhibiting PMEL17 processing in mice

Melanocytes of the hair follicle produce melanin and are essential in determining the differences in hair color. Pigment cell-specific MELanocyte Protein (PMEL17) plays a crucial role in melanogenesis. One of the critical steps is the amyloid-like functional oligomerization of PMEL17. Beta Site APP...

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Detalles Bibliográficos
Autores principales: Shimshek, Derya R., Jacobson, Laura H., Kolly, Carine, Zamurovic, Natasa, Balavenkatraman, Kamal Kumar, Morawiec, Laurent, Kreutzer, Robert, Schelle, Juliane, Jucker, Mathias, Bertschi, Barbara, Theil, Diethilde, Heier, Annabelle, Bigot, Karine, Beltz, Karen, Machauer, Rainer, Brzak, Irena, Perrot, Ludovic, Neumann, Ulf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766495/
https://www.ncbi.nlm.nih.gov/pubmed/26912421
http://dx.doi.org/10.1038/srep21917

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