Cargando…

T-Cell Immunity to Influenza in Older Adults: A Pathophysiological Framework for Development of More Effective Vaccines

One of the most profound public health consequences of immune senescence is reflected in an increased susceptibility to influenza and other acute respiratory illnesses, as well as a loss of influenza vaccine effectiveness in older people. Common medical conditions and mental and psychosocial health...

Descripción completa

Detalles Bibliográficos
Autores principales:	McElhaney, Janet E., Kuchel, George A., Zhou, Xin, Swain, Susan L., Haynes, Laura
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2016
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766518/ https://www.ncbi.nlm.nih.gov/pubmed/26941738 http://dx.doi.org/10.3389/fimmu.2016.00041

Ejemplares similares

Impact of Aging and Cytomegalovirus on Immunological Response to Influenza Vaccination and Infection
por: Merani, Shahzma, et al.
Publicado: (2017)

The immune response to influenza in older humans: beyond immune senescence
por: McElhaney, Janet E., et al.
Publicado: (2020)

Antibody and Cell-Mediated Immune Responses Are Correlates of Protection against Influenza Infection in Vaccinated Older Adults
por: Verschoor, Chris P., et al.
Publicado: (2021)

Granzyme B: A Double-Edged Sword in the Response to Influenza Infection in Vaccinated Older Adults
por: Verschoor, Chris P., et al.
Publicado: (2021)

Key Determinants of Cell-Mediated Immune Responses: A Randomized Trial of High Dose Vs. Standard Dose Split-Virus Influenza Vaccine in Older Adults
por: Verschoor, Chris P., et al.
Publicado: (2021)

Corrigendum: Key Determinants of Cell-Mediated Immune Responses: A Randomized Trial of High Dose Vs. Standard Dose Split-Virus Influenza Vaccine in Older Adults
por: Verschoor, Chris P., et al.
Publicado: (2021)

IL-2 and IL-6 cooperate to enhance the generation of influenza-specific CD8 T cells responding to live influenza virus in aged mice and humans
por: Zhou, Xin, et al.
Publicado: (2016)

Improving seasonal influenza vaccination for older adults
por: Pawelec, Graham, et al.
Publicado: (2021)

Vaccines for Improved Cellular Immunity to Influenza
por: Pawelec, Graham, et al.
Publicado: (2018)

Advanced biological age is associated with improved antibody responses in older high-dose influenza vaccine recipients over four consecutive seasons
por: Verschoor, Chris P., et al.
Publicado: (2022)

Frailty Is Associated With Increased Hemagglutination-Inhibition Titers in a 4-Year Randomized Trial Comparing Standard- and High-Dose Influenza Vaccination
por: Loeb, Nathalie, et al.
Publicado: (2020)

Recent advances in influenza vaccines
por: Pawelec, Graham, et al.
Publicado: (2020)

Immunosenescence and Influenza Vaccine Efficacy
por: Sambhara, Suryaprakash, et al.
Publicado: (2009)

Predictors of the antibody response to influenza vaccination in older adults with type 2 diabetes
por: McElhaney, Janet E, et al.
Publicado: (2015)

Markers of systemic inflammation are positively associated with influenza vaccine antibody responses with a possible role for ILT2(+)CD57(+) NK-cells
por: Picard, Emilie, et al.
Publicado: (2022)

Unanticipated efficacy of SARS-CoV-2 vaccination in older adults
por: Pawelec, Graham, et al.
Publicado: (2021)

Impact of Age, Caloric Restriction, and Influenza Infection on Mouse Gut Microbiome: An Exploratory Study of the Role of Age-Related Microbiome Changes on Influenza Responses
por: Bartley, Jenna M., et al.
Publicado: (2017)

Immunosenescence Modulation by Vaccination
por: McElhaney, Janet E.
Publicado: (2008)

Immunosenescence Modulation by Vaccination
por: McElhaney, Janet E.
Publicado: (2019)

Influenza-Specific T Cells from Older People Are Enriched in the Late Effector Subset and Their Presence Inversely Correlates with Vaccine Response
por: Wagar, Lisa E., et al.
Publicado: (2011)

Age and frailty in COVID-19 vaccine development
por: Andrew, Melissa K, et al.
Publicado: (2021)

Cytomegalovirus Seropositivity Predicts a Decline in the T Cell But Not the Antibody Response to Influenza in Vaccinated Older Adults Independent of Type 2 Diabetes Status
por: Haq, Kamran, et al.
Publicado: (2017)

Reliable reference genes for the quantification of mRNA in human T-cells and PBMCs stimulated with live influenza virus
por: Roy, Justin G., et al.
Publicado: (2020)

Sex Differences in Older Adults' Immune Responses to Seasonal Influenza Vaccination
por: Voigt, Emily A., et al.
Publicado: (2019)

Efficacy and Safety of CVT-E002, a Proprietary Extract of Panax quinquefolius in the Prevention of Respiratory Infections in Influenza-Vaccinated Community-Dwelling Adults: A Multicenter, Randomized, Double-Blind, and Placebo-Controlled Trial
por: McElhaney, Janet E., et al.
Publicado: (2011)

No evidence of a link between influenza vaccines and Guillain–Barre syndrome–associated antiganglioside antibodies
por: Wang, David J., et al.
Publicado: (2011)

Influence of Obesity on Pneumococcus Infection Risk in the Elderly
por: Frasca, Daniela, et al.
Publicado: (2019)

A Contributing Role for Anti-Neuraminidase Antibodies on Immunity to Pandemic H1N1 2009 Influenza A Virus
por: Marcelin, Glendie, et al.
Publicado: (2011)

Results of a Safety Pooled Analysis of an Adjuvanted Herpes Zoster Subunit Vaccine in More than 14,500 Participants Aged 50 Years or Older
por: López-Fauqued, Marta, et al.
Publicado: (2017)

ENDOCRINES AND THEIR RELATION TO INFLUENZA VIRUS INFECTION
por: Kalter, Seymour S., et al.
Publicado: (1951)

NK- and T-cell granzyme B and K expression correlates with age, CMV infection and influenza vaccine-induced antibody titres in older adults
por: Verschoor, Chris P., et al.
Publicado: (2023)

Improved Immune Responses in Young and Aged Mice with Adjuvanted Vaccines against H1N1 Influenza Infection
por: Baldwin, Susan L., et al.
Publicado: (2018)

Cross-Protective Immune Responses Induced by Sequential Influenza Virus Infection and by Sequential Vaccination With Inactivated Influenza Vaccines
por: Dong, Wei, et al.
Publicado: (2018)

Considering Frailty in SARS-CoV-2 Vaccine Development: How Geriatricians Can Assist
por: Andrew, Melissa K, et al.
Publicado: (2021)

Knowledge, attitudes, beliefs and behaviours of older adults about pneumococcal immunization, a Public Health Agency of Canada/Canadian Institutes of Health Research Influenza Research Network (PCIRN) investigation
por: Schneeberg, Amy, et al.
Publicado: (2014)

Heterosubtypic T-Cell Immunity to Influenza in Humans: Challenges for Universal T-Cell Influenza Vaccines
por: Sridhar, Saranya
Publicado: (2016)

Protective Intranasal Immunization Against Influenza Virus in Infant Mice Is Dependent on IL-6
por: Bonney, Elizabeth Ann, et al.
Publicado: (2020)

Influenza Viruses: Innate Immunity and mRNA Vaccines
por: Lee, SangJoon, et al.
Publicado: (2021)

Immune interference in effectiveness of influenza and COVID-19 vaccination
por: Xie, Yiwen, et al.
Publicado: (2023)

The disease burden of influenza beyond respiratory illness()
por: Macias, Alejandro E., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_lvriadgu36c8e9fv8ln1cq19h1