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Histopathological nerve and skeletal muscle changes in rats subjected to persistent insulin-induced hypoglycemia

New insulin analogues with a longer duration of action and a flatter pharmacodynamic profile are developed to improve convenience and safety for diabetic patients. During the nonclinical development of such analogues, safety studies must be conducted in nondiabetic rats, which consequently are rende...

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Detalles Bibliográficos
Autores principales:	Jensen, Vivi Flou Hjorth, Mølck, Anne-Marie, Heydenreich, Annette, Jensen, Karin Juul, Bertelsen, Line Olrik, Alifrangis, Lene, Andersen, Lene, Søeborg, Henrik, Chapman, Melissa, Lykkesfeldt, Jens, Bøgh, Ingrid Brück
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Japanese Society of Toxicologic Pathology 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766526/ https://www.ncbi.nlm.nih.gov/pubmed/26989298 http://dx.doi.org/10.1293/tox.2015-0041

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