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8-Oxoguanine accumulation in mitochondrial DNA causes mitochondrial dysfunction and impairs neuritogenesis in cultured adult mouse cortical neurons under oxidative conditions

Oxidative stress and mitochondrial dysfunction are implicated in aging-related neurodegenerative disorders. 8-Oxoguanine (8-oxoG), a common oxidised base lesion, is often highly accumulated in brains from patients with neurodegenerative disorders. MTH1 hydrolyses 8-oxo-2′-deoxyguanosine triphosphate...

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Detalles Bibliográficos
Autores principales:	Leon, Julio, Sakumi, Kunihiko, Castillo, Erika, Sheng, Zijing, Oka, Sugako, Nakabeppu, Yusaku
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766534/ https://www.ncbi.nlm.nih.gov/pubmed/26912170 http://dx.doi.org/10.1038/srep22086

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