Cargando…

Inhibition of the STAT3 signaling pathway contributes to apigenin-mediated anti-metastatic effect in melanoma

Signal transducer and activator of transcription 3 (STAT3) signaling is constantly activated in human melanoma, and promotes melanoma metastasis. The dietary flavonoid apigenin is a bioactive compound that possesses low toxicity and exerts anti-metastatic activity in melanoma. However, the anti-meta...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cao, Hui-Hui, Chu, Jian-Hong, Kwan, Hiu-Yee, Su, Tao, Yu, Hua, Cheng, Chi-Yan, Fu, Xiu-Qiong, Guo, Hui, Li, Ting, Tse, Anfernee Kai-Wing, Chou, Gui-Xin, Mo, Huan-Biao, Yu, Zhi-Ling
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766576/ https://www.ncbi.nlm.nih.gov/pubmed/26911838 http://dx.doi.org/10.1038/srep21731

Ejemplares similares

Quercetin inhibits HGF/c-Met signaling and HGF-stimulated melanoma cell migration and invasion
por: Cao, Hui-Hui, et al.
Publicado: (2015)

Comparison of the toxicities, activities and chemical profiles of raw and processed Xanthii Fructus
por: Su, Tao, et al.
Publicado: (2016)

Sensitization of melanoma cells to alkylating agent-induced DNA damage and cell death via orchestrating oxidative stress and IKKβ inhibition
por: Tse, Anfernee Kai-Wing, et al.
Publicado: (2017)

A herbal formula comprising Rosae Multiflorae Fructus and Lonicerae Japonicae Flos, attenuates collagen-induced arthritis and inhibits TLR4 signalling in rats
por: Cheng, Brian Chi Yan, et al.
Publicado: (2016)

Inhibiting STAT3 signaling is involved in the anti-melanoma effects of a herbal formula comprising Sophorae Flos and Lonicerae Japonicae Flos
por: Li, Ting, et al.
Publicado: (2017)

Icariside II overcomes TRAIL resistance of melanoma cells through ROS-mediated downregulation of STAT3/cFLIP signaling
por: Du, Juan, et al.
Publicado: (2016)

Icaritin, a novel FASN inhibitor, exerts anti-melanoma activities through IGF-1R/STAT3 signaling
por: Wu, Jinfeng, et al.
Publicado: (2016)

Apigenin inhibits colonic inflammation and tumorigenesis by suppressing STAT3-NF-κB signaling
por: Ai, Xiao-Yu, et al.
Publicado: (2017)

Antrodia camphorata Mycelia Exert Anti-liver Cancer Effects and Inhibit STAT3 Signaling in vitro and in vivo
por: Zhu, Pei-Li, et al.
Publicado: (2018)

Activation of STAT3 is a key event in TLR4 signaling-mediated melanoma progression
por: Fu, Xiu-Qiong, et al.
Publicado: (2020)

Inhibition of Epstein-Barr virus reactivation by the flavonoid apigenin
por: Wu, Chung-Chun, et al.
Publicado: (2017)

Schisandrin B regulates lipid metabolism in subcutaneous adipocytes
por: Kwan, Hiu Yee, et al.
Publicado: (2017)

LRG1 Promotes Metastatic Dissemination of Melanoma through Regulating EGFR/STAT3 Signalling
por: Kwan, Yuet Ping, et al.
Publicado: (2021)

Brevilin A is a potent anti-metastatic CRC agent that targets the VEGF-IL6-STAT3 axis in the HSCs-CRC interplay
por: Fan, Xueying, et al.
Publicado: (2023)

Brevilin A exerts anti-colorectal cancer effects and potently inhibits STAT3 signaling invitro
por: Meng, Mingjing, et al.
Publicado: (2023)

Inhibition of the STAT3 Signaling Pathway Contributes to the Anti-Melanoma Activities of Shikonin
por: Cao, Hui-Hui, et al.
Publicado: (2020)

Cinnamon induces browning in subcutaneous adipocytes
por: Kwan, Hiu Yee, et al.
Publicado: (2017)

Naringenin and apigenin ameliorates corticosterone-induced depressive behaviors
por: Zhang, Li, et al.
Publicado: (2023)

Ribosome-Inactivating Protein α-Momorcharin Derived from Edible Plant Momordica charantia Induces Inflammatory Responses by Activating the NF-kappaB and JNK Pathways
por: Chen, Ying-Jie, et al.
Publicado: (2019)

Comparison of the chemical profiles and inflammatory mediator-inhibitory effects of three Siegesbeckia herbs used as Herba Siegesbeckiae (Xixiancao)
por: Guo, Hui, et al.
Publicado: (2018)

Anti-Inflammatory Effect of an Apigenin-Maillard Reaction Product in Macrophages and Macrophage-Endothelial Cocultures
por: Zhou, Qian, et al.
Publicado: (2019)

Metabolomics reveals the mechanisms for the cardiotoxicity of Pinelliae Rhizoma and the toxicity-reducing effect of processing
por: Su, Tao, et al.
Publicado: (2016)

Protective Roles of Apigenin Against Cardiometabolic Diseases: A Systematic Review
por: Xu, Yajie, et al.
Publicado: (2022)

Apigenin-induced lysosomal degradation of β-catenin in Wnt/β-catenin signaling
por: Lin, Chung-Ming, et al.
Publicado: (2017)

The Therapeutic Potential of Apigenin
por: Salehi, Bahare, et al.
Publicado: (2019)

Anticancer Effects and Molecular Mechanisms of Apigenin in Cervical Cancer Cells
por: Chen, Ya-Hui, et al.
Publicado: (2022)

Apigenin and luteolin modulate microglial activation via inhibition of STAT1-induced CD40 expression
por: Rezai-Zadeh, Kavon, et al.
Publicado: (2008)

Apigenin ameliorates hepatic lipid accumulation by activating the autophagy-mitochondria pathway
por: Hsu, Man-Chen, et al.
Publicado: (2021)

Apigenin-7-O-glucoside versus apigenin: Insight into the modes of anticandidal and cytotoxic actions
por: Smiljkovic, Marija, et al.
Publicado: (2017)

Metastatic Melanoma Cells Evade Immune Detection by Silencing STAT1
por: Osborn, JoDi Lynn, et al.
Publicado: (2015)

Lipidomic-based investigation into the regulatory effect of Schisandrin B on palmitic acid level in non-alcoholic steatotic livers
por: Kwan, Hiu Yee, et al.
Publicado: (2015)

Effects of Apigenin and Apigenin- Loaded Nanogel on Induction of Apoptosis in Human Chronic Myeloid Leukemia Cells
por: Samadian, Nooshin, et al.
Publicado: (2018)

Apigenin Attenuates Melanoma Cell Migration by Inducing Anoikis through Integrin and Focal Adhesion Kinase Inhibition
por: Hasnat, Md. Abul, et al.
Publicado: (2015)

Apigenin induces apoptosis by regulating Akt and MAPK pathways in human melanoma cell A375SM
por: Woo, Joong-Seok, et al.
Publicado: (2020)

Encapsulation and Characterization of Nanoemulsions Based on an Anti-oxidative Polymeric Amphiphile for Topical Apigenin Delivery
por: Chou, Tzung-Han, et al.
Publicado: (2021)

Apigenin inhibits fibroblast proliferation and reduces epidural fibrosis by regulating Wnt3a/β-catenin signaling pathway
por: Jiao, Rui, et al.
Publicado: (2019)

Recent insights into the biological functions of apigenin
por: Kim, Jae Kwang, et al.
Publicado: (2020)

STAT3 but Not STAT5 Contributes to the Protective Effect of Electroacupuncture Against Myocardial Ischemia/Reperfusion Injury in Mice
por: Guo, Hui-Hui, et al.
Publicado: (2021)

Apigenin and Ethaverine Hydrochloride Enhance Retinal Vascular Barrier In Vitro and In Vivo
por: Jiang, Weiwei, et al.
Publicado: (2020)

Apigenin suppresses PD-L1 expression in melanoma and host dendritic cells to elicit synergistic therapeutic effects
por: Xu, Lu, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_pddbj4m4cn7ju0j0bvh4o33uj6