The anti-oxidative transcription factor Nuclear factor E2 related factor-2 (Nrf2) counteracts TGF-β1 mediated growth inhibition of pancreatic ductal epithelial cells -Nrf2 as determinant of pro-tumorigenic functions of TGF-β1

BACKGROUND: Nuclear factor E2 related factor-2 (Nrf2) is an oxidative stress inducible transcription factor being essential in regulating cell homeostasis. Thus, acute induction of Nrf2 in epithelial cells exposed to inflammation confers protection from oxidative cell damage and mutagenesis supporti...

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Detalles Bibliográficos
Autores principales: Genrich, Geeske, Kruppa, Marcus, Lenk, Lennart, Helm, Ole, Broich, Anna, Freitag-Wolf, Sandra, Röcken, Christoph, Sipos, Bence, Schäfer, Heiner, Sebens, Susanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766703/
https://www.ncbi.nlm.nih.gov/pubmed/26915435
http://dx.doi.org/10.1186/s12885-016-2191-7

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