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Trimming of sequence reads alters RNA-Seq gene expression estimates

BACKGROUND: High-throughput RNA-Sequencing (RNA-Seq) has become the preferred technique for studying gene expression differences between biological samples and for discovering novel isoforms, though the techniques to analyze the resulting data are still immature. One pre-processing step that is wide...

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Detalles Bibliográficos
Autores principales: Williams, Claire R., Baccarella, Alyssa, Parrish, Jay Z., Kim, Charles C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766705/
https://www.ncbi.nlm.nih.gov/pubmed/26911985
http://dx.doi.org/10.1186/s12859-016-0956-2