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Cellular immune activity biomarker neopterin is associated hyperlipidemia: results from a large population-based study
BACKGROUND: Increased serum neopterin had been described in older age two decades ago. Neopterin is a biomarker of systemic adaptive immune activation that could be potentially implicated in metabolic syndrome (MetS). Measurements of waist circumference, triglycerides, high-density lipoprotein chole...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766742/ https://www.ncbi.nlm.nih.gov/pubmed/26918023 http://dx.doi.org/10.1186/s12979-016-0059-y |
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| author | Chuang, Shu-Chun Boeing, Heiner Vollset, Stein Emil Midttun, Øivind Ueland, Per Magne Bueno-de-Mesquita, Bas Lajous, Martin Fagherazzi, Guy Boutron-Ruault, Marie-Christine Kaaks, Rudolf Küehn, Tilman Pischon, Tobias Drogan, Dagmar Tjønneland, Anne Overvad, Kim Quirós, J Ramón Agudo, Antonio Molina-Montes, Esther Dorronsoro, Miren Huerta, José María Barricarte, Aurelio Khaw, Kay-Tee Wareham, Nicholas J. Travis, Ruth C. Trichopoulou, Antonia Lagiou, Pagona Trichopoulos, Dimitrios Masala, Giovanna Agnoli, Claudia Tumino, Rosario Mattiello, Amalia Peeters, Petra H Weiderpass, Elisabete Palmqvist, Richard Ljuslinder, Ingrid Gunter, Marc Lu, Yunxia Cross, Amanda J. Riboli, Elio Vineis, Paolo Aleksandrova, Krasimira |
| author_facet | Chuang, Shu-Chun Boeing, Heiner Vollset, Stein Emil Midttun, Øivind Ueland, Per Magne Bueno-de-Mesquita, Bas Lajous, Martin Fagherazzi, Guy Boutron-Ruault, Marie-Christine Kaaks, Rudolf Küehn, Tilman Pischon, Tobias Drogan, Dagmar Tjønneland, Anne Overvad, Kim Quirós, J Ramón Agudo, Antonio Molina-Montes, Esther Dorronsoro, Miren Huerta, José María Barricarte, Aurelio Khaw, Kay-Tee Wareham, Nicholas J. Travis, Ruth C. Trichopoulou, Antonia Lagiou, Pagona Trichopoulos, Dimitrios Masala, Giovanna Agnoli, Claudia Tumino, Rosario Mattiello, Amalia Peeters, Petra H Weiderpass, Elisabete Palmqvist, Richard Ljuslinder, Ingrid Gunter, Marc Lu, Yunxia Cross, Amanda J. Riboli, Elio Vineis, Paolo Aleksandrova, Krasimira |
| author_sort | Chuang, Shu-Chun |
| collection | PubMed |
| description | BACKGROUND: Increased serum neopterin had been described in older age two decades ago. Neopterin is a biomarker of systemic adaptive immune activation that could be potentially implicated in metabolic syndrome (MetS). Measurements of waist circumference, triglycerides, high-density lipoprotein cholesterol (HDLC), systolic and diastolic blood pressure, glycated hemoglobin as components of MetS definition, and plasma total neopterin concentrations were performed in 594 participants recruited in the European Prospective Investigation into Cancer and Nutrition (EPIC). RESULTS: Higher total neopterin concentrations were associated with reduced HDLC (9.7 %, p < 0.01 for men and 9.2 %, p < 0.01 for women), whereas no association was observed with the rest of the MetS components as well as with MetS overall (per 10 nmol/L: OR = 1.42, 95 % CI = 0.85-2.39 for men and OR = 1.38, 95 % CI = 0.79-2.43). CONCLUSIONS: These data suggest that high total neopterin concentrations are cross-sectionally associated with reduced HDLC, but not with overall MetS. |
| format | Online Article Text |
| id | pubmed-4766742 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2016 |
| publisher | BioMed Central |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-47667422016-02-26 Cellular immune activity biomarker neopterin is associated hyperlipidemia: results from a large population-based study Chuang, Shu-Chun Boeing, Heiner Vollset, Stein Emil Midttun, Øivind Ueland, Per Magne Bueno-de-Mesquita, Bas Lajous, Martin Fagherazzi, Guy Boutron-Ruault, Marie-Christine Kaaks, Rudolf Küehn, Tilman Pischon, Tobias Drogan, Dagmar Tjønneland, Anne Overvad, Kim Quirós, J Ramón Agudo, Antonio Molina-Montes, Esther Dorronsoro, Miren Huerta, José María Barricarte, Aurelio Khaw, Kay-Tee Wareham, Nicholas J. Travis, Ruth C. Trichopoulou, Antonia Lagiou, Pagona Trichopoulos, Dimitrios Masala, Giovanna Agnoli, Claudia Tumino, Rosario Mattiello, Amalia Peeters, Petra H Weiderpass, Elisabete Palmqvist, Richard Ljuslinder, Ingrid Gunter, Marc Lu, Yunxia Cross, Amanda J. Riboli, Elio Vineis, Paolo Aleksandrova, Krasimira Immun Ageing Research BACKGROUND: Increased serum neopterin had been described in older age two decades ago. Neopterin is a biomarker of systemic adaptive immune activation that could be potentially implicated in metabolic syndrome (MetS). Measurements of waist circumference, triglycerides, high-density lipoprotein cholesterol (HDLC), systolic and diastolic blood pressure, glycated hemoglobin as components of MetS definition, and plasma total neopterin concentrations were performed in 594 participants recruited in the European Prospective Investigation into Cancer and Nutrition (EPIC). RESULTS: Higher total neopterin concentrations were associated with reduced HDLC (9.7 %, p < 0.01 for men and 9.2 %, p < 0.01 for women), whereas no association was observed with the rest of the MetS components as well as with MetS overall (per 10 nmol/L: OR = 1.42, 95 % CI = 0.85-2.39 for men and OR = 1.38, 95 % CI = 0.79-2.43). CONCLUSIONS: These data suggest that high total neopterin concentrations are cross-sectionally associated with reduced HDLC, but not with overall MetS. BioMed Central 2016-02-25 /pmc/articles/PMC4766742/ /pubmed/26918023 http://dx.doi.org/10.1186/s12979-016-0059-y Text en © Chuang et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| spellingShingle | Research Chuang, Shu-Chun Boeing, Heiner Vollset, Stein Emil Midttun, Øivind Ueland, Per Magne Bueno-de-Mesquita, Bas Lajous, Martin Fagherazzi, Guy Boutron-Ruault, Marie-Christine Kaaks, Rudolf Küehn, Tilman Pischon, Tobias Drogan, Dagmar Tjønneland, Anne Overvad, Kim Quirós, J Ramón Agudo, Antonio Molina-Montes, Esther Dorronsoro, Miren Huerta, José María Barricarte, Aurelio Khaw, Kay-Tee Wareham, Nicholas J. Travis, Ruth C. Trichopoulou, Antonia Lagiou, Pagona Trichopoulos, Dimitrios Masala, Giovanna Agnoli, Claudia Tumino, Rosario Mattiello, Amalia Peeters, Petra H Weiderpass, Elisabete Palmqvist, Richard Ljuslinder, Ingrid Gunter, Marc Lu, Yunxia Cross, Amanda J. Riboli, Elio Vineis, Paolo Aleksandrova, Krasimira Cellular immune activity biomarker neopterin is associated hyperlipidemia: results from a large population-based study |
| title | Cellular immune activity biomarker neopterin is associated hyperlipidemia: results from a large population-based study |
| title_full | Cellular immune activity biomarker neopterin is associated hyperlipidemia: results from a large population-based study |
| title_fullStr | Cellular immune activity biomarker neopterin is associated hyperlipidemia: results from a large population-based study |
| title_full_unstemmed | Cellular immune activity biomarker neopterin is associated hyperlipidemia: results from a large population-based study |
| title_short | Cellular immune activity biomarker neopterin is associated hyperlipidemia: results from a large population-based study |
| title_sort | cellular immune activity biomarker neopterin is associated hyperlipidemia: results from a large population-based study |
| topic | Research |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766742/ https://www.ncbi.nlm.nih.gov/pubmed/26918023 http://dx.doi.org/10.1186/s12979-016-0059-y |
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