Cargando…
Risk factors for lung diseases after renal transplantation
BACKGROUND: Lung diseases are one of the major causes of morbidity and mortality after renal transplantation. The aim of the study is to define the risk factors for infectious and noninfectious pulmonary complications in kidney transplant patients. MATERIALS AND METHODS: We prospectively studied 267...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766817/ https://www.ncbi.nlm.nih.gov/pubmed/26958045 http://dx.doi.org/10.4103/1735-1995.172978 |
_version_ | 1782417736768421888 |
---|---|
author | Pencheva, Ventsislava P. Petrova, Daniela S. Genov, Diyan K. Georgiev, Ognian B. |
author_facet | Pencheva, Ventsislava P. Petrova, Daniela S. Genov, Diyan K. Georgiev, Ognian B. |
author_sort | Pencheva, Ventsislava P. |
collection | PubMed |
description | BACKGROUND: Lung diseases are one of the major causes of morbidity and mortality after renal transplantation. The aim of the study is to define the risk factors for infectious and noninfectious pulmonary complications in kidney transplant patients. MATERIALS AND METHODS: We prospectively studied 267 patients after renal transplantation. The kidney recipients were followed-up for the development of pulmonary complications for a period of 7 years. Different noninvasive and invasive diagnostic tests were used in cases suspected of lung disease. RESULTS: The risk factors associated with the development of pulmonary complications were diabetes mellitus (odds ratio [OR] = 4.60; P = 0.001), arterial hypertension (OR = 1.95; P = 0.015), living related donor (OR = 2.69; P = 0.004), therapy for acute graft rejection (OR = 2.06; P = 0.038), immunosuppressive regimens that includes mycophenolate (OR = 2.40; P = 0.011), azathioprine (OR = 2.25; P = 0.023), and tacrolimus (OR = 1.83; P = 0.041). The only factor associated with the lower risk of complications was a positive serology test for Cytomegalovirus of the recipient before transplantation (OR = 0.1412; P = 0.001). CONCLUSION: The risk factors can be used to identify patients at increased risk for posttransplant lung diseases. Monitoring of higher-risk patients allow timely diagnosis and early adequate treatment and can reduce the morbidity and mortality after renal transplantation. |
format | Online Article Text |
id | pubmed-4766817 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-47668172016-03-08 Risk factors for lung diseases after renal transplantation Pencheva, Ventsislava P. Petrova, Daniela S. Genov, Diyan K. Georgiev, Ognian B. J Res Med Sci Original Article BACKGROUND: Lung diseases are one of the major causes of morbidity and mortality after renal transplantation. The aim of the study is to define the risk factors for infectious and noninfectious pulmonary complications in kidney transplant patients. MATERIALS AND METHODS: We prospectively studied 267 patients after renal transplantation. The kidney recipients were followed-up for the development of pulmonary complications for a period of 7 years. Different noninvasive and invasive diagnostic tests were used in cases suspected of lung disease. RESULTS: The risk factors associated with the development of pulmonary complications were diabetes mellitus (odds ratio [OR] = 4.60; P = 0.001), arterial hypertension (OR = 1.95; P = 0.015), living related donor (OR = 2.69; P = 0.004), therapy for acute graft rejection (OR = 2.06; P = 0.038), immunosuppressive regimens that includes mycophenolate (OR = 2.40; P = 0.011), azathioprine (OR = 2.25; P = 0.023), and tacrolimus (OR = 1.83; P = 0.041). The only factor associated with the lower risk of complications was a positive serology test for Cytomegalovirus of the recipient before transplantation (OR = 0.1412; P = 0.001). CONCLUSION: The risk factors can be used to identify patients at increased risk for posttransplant lung diseases. Monitoring of higher-risk patients allow timely diagnosis and early adequate treatment and can reduce the morbidity and mortality after renal transplantation. Medknow Publications & Media Pvt Ltd 2015-12 /pmc/articles/PMC4766817/ /pubmed/26958045 http://dx.doi.org/10.4103/1735-1995.172978 Text en Copyright: © 2015 Journal of Research in Medical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Pencheva, Ventsislava P. Petrova, Daniela S. Genov, Diyan K. Georgiev, Ognian B. Risk factors for lung diseases after renal transplantation |
title | Risk factors for lung diseases after renal transplantation |
title_full | Risk factors for lung diseases after renal transplantation |
title_fullStr | Risk factors for lung diseases after renal transplantation |
title_full_unstemmed | Risk factors for lung diseases after renal transplantation |
title_short | Risk factors for lung diseases after renal transplantation |
title_sort | risk factors for lung diseases after renal transplantation |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766817/ https://www.ncbi.nlm.nih.gov/pubmed/26958045 http://dx.doi.org/10.4103/1735-1995.172978 |
work_keys_str_mv | AT penchevaventsislavap riskfactorsforlungdiseasesafterrenaltransplantation AT petrovadanielas riskfactorsforlungdiseasesafterrenaltransplantation AT genovdiyank riskfactorsforlungdiseasesafterrenaltransplantation AT georgievognianb riskfactorsforlungdiseasesafterrenaltransplantation |