Estrogen Receptor Alpha (ESR1) Single-Nucleotide Polymorphisms (SNPs) Affect Malignant Melanoma Susceptibility and Disease Course

The incidence of malignant melanoma in the developed world is continuously increasing. We conducted a case–control study in order to evaluate the association between each of the four estrogen receptor alpha polymorphisms (ESR1 single-nucleotide polymorphisms [SNPs] +2464C/T, −4576A/C, +1619A/G, and...

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Detalles Bibliográficos
Autores principales: Glatthaar, Hanna, Katto, Judith, Vogt, Thomas, Mahlknecht, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767130/
https://www.ncbi.nlm.nih.gov/pubmed/26949342
http://dx.doi.org/10.4137/GEG.S31264
Descripción
Sumario:The incidence of malignant melanoma in the developed world is continuously increasing. We conducted a case–control study in order to evaluate the association between each of the four estrogen receptor alpha polymorphisms (ESR1 single-nucleotide polymorphisms [SNPs] +2464C/T, −4576A/C, +1619A/G, and +6362C/T) and malignant melanoma susceptibility and disease course. The study population consisted of 205 Caucasian patients who were diagnosed as having malignant melanoma and 208 healthy Caucasian controls. Through DNA genotyping, we identified a SNP-dependent malignant melanoma susceptibility as well as a SNP-dependent effect on the course of disease and response to therapy.

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