Estrogen Receptor Alpha (ESR1) Single-Nucleotide Polymorphisms (SNPs) Affect Malignant Melanoma Susceptibility and Disease Course

The incidence of malignant melanoma in the developed world is continuously increasing. We conducted a case–control study in order to evaluate the association between each of the four estrogen receptor alpha polymorphisms (ESR1 single-nucleotide polymorphisms [SNPs] +2464C/T, −4576A/C, +1619A/G, and...

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Autores principales: Glatthaar, Hanna, Katto, Judith, Vogt, Thomas, Mahlknecht, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767130/
https://www.ncbi.nlm.nih.gov/pubmed/26949342
http://dx.doi.org/10.4137/GEG.S31264
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author Glatthaar, Hanna
Katto, Judith
Vogt, Thomas
Mahlknecht, Ulrich
author_facet Glatthaar, Hanna
Katto, Judith
Vogt, Thomas
Mahlknecht, Ulrich
author_sort Glatthaar, Hanna
collection PubMed
description The incidence of malignant melanoma in the developed world is continuously increasing. We conducted a case–control study in order to evaluate the association between each of the four estrogen receptor alpha polymorphisms (ESR1 single-nucleotide polymorphisms [SNPs] +2464C/T, −4576A/C, +1619A/G, and +6362C/T) and malignant melanoma susceptibility and disease course. The study population consisted of 205 Caucasian patients who were diagnosed as having malignant melanoma and 208 healthy Caucasian controls. Through DNA genotyping, we identified a SNP-dependent malignant melanoma susceptibility as well as a SNP-dependent effect on the course of disease and response to therapy.
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spelling pubmed-47671302016-03-04 Estrogen Receptor Alpha (ESR1) Single-Nucleotide Polymorphisms (SNPs) Affect Malignant Melanoma Susceptibility and Disease Course Glatthaar, Hanna Katto, Judith Vogt, Thomas Mahlknecht, Ulrich Genet Epigenet Original Research The incidence of malignant melanoma in the developed world is continuously increasing. We conducted a case–control study in order to evaluate the association between each of the four estrogen receptor alpha polymorphisms (ESR1 single-nucleotide polymorphisms [SNPs] +2464C/T, −4576A/C, +1619A/G, and +6362C/T) and malignant melanoma susceptibility and disease course. The study population consisted of 205 Caucasian patients who were diagnosed as having malignant melanoma and 208 healthy Caucasian controls. Through DNA genotyping, we identified a SNP-dependent malignant melanoma susceptibility as well as a SNP-dependent effect on the course of disease and response to therapy. Libertas Academica 2016-02-24 /pmc/articles/PMC4767130/ /pubmed/26949342 http://dx.doi.org/10.4137/GEG.S31264 Text en © 2016 the author(s), publisher and licensee Libertas Academica Ltd. This is an open-access article distributed under the terms of the Creative Commons CC-BY-NC 3.0 License.
spellingShingle Original Research
Glatthaar, Hanna
Katto, Judith
Vogt, Thomas
Mahlknecht, Ulrich
Estrogen Receptor Alpha (ESR1) Single-Nucleotide Polymorphisms (SNPs) Affect Malignant Melanoma Susceptibility and Disease Course
title Estrogen Receptor Alpha (ESR1) Single-Nucleotide Polymorphisms (SNPs) Affect Malignant Melanoma Susceptibility and Disease Course
title_full Estrogen Receptor Alpha (ESR1) Single-Nucleotide Polymorphisms (SNPs) Affect Malignant Melanoma Susceptibility and Disease Course
title_fullStr Estrogen Receptor Alpha (ESR1) Single-Nucleotide Polymorphisms (SNPs) Affect Malignant Melanoma Susceptibility and Disease Course
title_full_unstemmed Estrogen Receptor Alpha (ESR1) Single-Nucleotide Polymorphisms (SNPs) Affect Malignant Melanoma Susceptibility and Disease Course
title_short Estrogen Receptor Alpha (ESR1) Single-Nucleotide Polymorphisms (SNPs) Affect Malignant Melanoma Susceptibility and Disease Course
title_sort estrogen receptor alpha (esr1) single-nucleotide polymorphisms (snps) affect malignant melanoma susceptibility and disease course
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767130/
https://www.ncbi.nlm.nih.gov/pubmed/26949342
http://dx.doi.org/10.4137/GEG.S31264
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