Platelet aggregation but not activation and degranulation during the acute post-ischemic reperfusion phase in livers with no underlying disease

BACKGROUND: Platelets and P-selectin (CD62P) play an unequivocal role in the pathology of hepatic ischemia/reperfusion (I/R) injury. Inhibition or knock-out of P-selectin or immunodepletion of platelets results in amelioration of post-ischemic inflammation, reduced hepatocellular damage, and improve...

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Detalles Bibliográficos
Autores principales: van Golen, Rowan F., Stevens, Katarzyna M., Colarusso, Pina, Jaeschke, Hartmut, Heger, Michal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Whioce Publishing Pte. Ltd. 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767188/
https://www.ncbi.nlm.nih.gov/pubmed/26925465

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