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Designing More Efficient Preclinical Experiments: A Simulation Study in Chemotherapy-Induced Myelosupression
A new more efficient preclinical study design (referred to as a compact design) is proposed that removes the need for satellite animals for the collection of toxicokinetic (TK) data by sampling from the main study animals, taking no more than one sample in 24 h to build up a full profile over the co...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767189/ https://www.ncbi.nlm.nih.gov/pubmed/26678701 http://dx.doi.org/10.1093/toxsci/kfv316 |