Novel and potent anti-tumor and anti-metastatic di-2-pyridylketone thiosemicarbazones demonstrate marked differences in pharmacology between the first and second generation lead agents

Di(2-pyridyl)ketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) and di(2-pyridyl)ketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC) are novel, highly potent and selective anti-tumor and anti-metastatic drugs. Despite their structural similarity, these agents differ in their efficacy and toxicity i...

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Detalles Bibliográficos
Autores principales: Sestak, Vit, Stariat, Jan, Cermanova, Jolana, Potuckova, Eliska, Chladek, Jaroslav, Roh, Jaroslav, Bures, Jan, Jansova, Hana, Prusa, Petr, Sterba, Martin, Micuda, Stanislav, Simunek, Tomas, Kalinowski, Danuta S., Richardson, Des R., Kovarikova, Petra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767442/
https://www.ncbi.nlm.nih.gov/pubmed/26623727

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