Predictive significance of DNA damage and repair biomarkers in triple-negative breast cancer patients treated with neoadjuvant chemotherapy: An exploratory analysis

Response of cancer cells to chemotherapy-induced DNA damage is regulated by the ATM-Chk2 and ATR-Chk1 pathways. We investigated the association between phosphorylated H2AX (γ-H2AX), a marker of DNA double-strand breaks that trigger the ATM-Chk2 cascade, and phosphorylated Chk1 (pChk1), with patholog...

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Detalles Bibliográficos
Autores principales: Vici, Patrizia, Benedetto, Anna Di, Ercolani, Cristiana, Pizzuti, Laura, Lauro, Luigi Di, Sergi, Domenico, Sperati, Francesca, Terrenato, Irene, Dattilo, Rosanna, Botti, Claudio, Fabi, Alessandra, Ramieri, Maria Teresa, Mentuccia, Lucia, Marinelli, Camilla, Iezzi, Laura, Gamucci, Teresa, Natoli, Clara, Vitale, Ilio, Barba, Maddalena, Mottolese, Marcella, De Maria, Ruggero, Maugeri-Saccà, Marcello
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767469/
https://www.ncbi.nlm.nih.gov/pubmed/26544894

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